Protein Info for OHPLBJKB_02359 in Escherichia coli HS(pFamp)R (ATCC 700891)

Annotation: Transcriptional regulatory protein TyrR

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 513 PF00158: Sigma54_activat" amino acids 207 to 365 (159 residues), 191.4 bits, see alignment E=2.4e-60 PF14532: Sigma54_activ_2" amino acids 208 to 370 (163 residues), 69.9 bits, see alignment E=6.9e-23 PF00004: AAA" amino acids 230 to 346 (117 residues), 21.5 bits, see alignment E=7e-08 PF18024: HTH_50" amino acids 458 to 507 (50 residues), 70.1 bits, see alignment 2.5e-23 TIGR04381: TyrR family helix-turn-helix domain" amino acids 460 to 507 (48 residues), 95.9 bits, see alignment 5.2e-32

Best Hits

Swiss-Prot: 100% identical to TYRR_ECOLI: Transcriptional regulatory protein TyrR (tyrR) from Escherichia coli (strain K12)

KEGG orthology group: K03721, transcriptional regulator of aroF, aroG, tyrA and aromatic amino acid transport (inferred from 100% identity to eco:b1323)

Predicted SEED Role

"Transcriptional repressor protein TyrR" in subsystem Common Pathway For Synthesis of Aromatic Compounds (DAHP synthase to chorismate) or Phenylalanine and Tyrosine Branches from Chorismate

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (513 amino acids)

>OHPLBJKB_02359 Transcriptional regulatory protein TyrR (Escherichia coli HS(pFamp)R (ATCC 700891))
MRLEVFCEDRLGLTRELLDLLVLRGIDLRGIEIDPIGRIYLNFAELEFESFSSLMAEIRR
IAGVTDVRTVPWMPSEREHLALSALLEALPEPVLSVDMKSKVDMANPASCQLFGQKLDRL
RNHTAAQLINGFNFLRWLESEPQDSHNEHVVINGQNFLMEITPVYLQDENDQHVLTGAVV
MLRSTIRMGRQLQNVAAQDVSAFSQIVAVSPKMKHVVEQAQKLAMLSAPLLITGDTGTGK
DLFAYACHQASPRAGKPYLALNCASIPEDAVESELFGHAPEGKKGFFEQANGGSVLLDEI
GEMSPRMQAKLLRFLNDGTFRRVGEDHEVHVDVRVICATQKNLVELVQKGMFREDLYYRL
NVLTLNLPPLRDCPQDIMPLTELFVARFADEQGVPRPKLAADLNTVLTRYAWPGNVRQLK
NAIYRALTQLDGYELRPQDILLPDYDAATVAVGEDAMEGSLDEITSRFERSVLTQLYRNY
PSTRKLAKRLGVSHTAIANKLREYGLSQKKNEE