Protein Info for NIAGMN_28690 in Escherichia coli ECRC102

Name: repA
Annotation: incFII family plasmid replication initiator RepA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 285 TIGR03474: incFII family plasmid replication initiator RepA" amino acids 9 to 283 (275 residues), 580.7 bits, see alignment E=1.8e-179 PF02387: IncFII_repA" amino acids 12 to 244 (233 residues), 92.2 bits, see alignment E=1.9e-30

Best Hits

Swiss-Prot: 96% identical to REPA2_ECOLX: Replication initiation protein (repA) from Escherichia coli

KEGG orthology group: None (inferred from 100% identity to ecs:pO157p68)

Predicted SEED Role

"RepA1"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (285 amino acids)

>NIAGMN_28690 incFII family plasmid replication initiator RepA (Escherichia coli ECRC102)
VTDLQQTYYRQVKNPNPVFTPREGAGTLKFCEKLMEKAVGFTSRFDFAIHVAHARSKGLR
RRMPPVLRRRAIDALLQGLCFHYDPLANRVQCSITTLAIECGLATESAAGKLSITRATRA
LTFLSELGLITYQTEYDPLIGCYIPTDITFTPALFAALDVSEDAVAAARRSRVEWENRLR
KKQGLDTLGMDELIAKAWRFVRERFRSYQTELKSRGIKRARARRDAGRERQDIVTLVKRQ
LTREISEGRFTANREAVKREVERRVKERMILSRNRNYSRLATASP