Protein Info for NIAGMN_21355 in Escherichia coli ECRC102

Name: uhpC
Annotation: aromatic acid/H+ symport family MFS transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 452 transmembrane" amino acids 21 to 45 (25 residues), see Phobius details amino acids 59 to 77 (19 residues), see Phobius details amino acids 89 to 107 (19 residues), see Phobius details amino acids 113 to 133 (21 residues), see Phobius details amino acids 145 to 167 (23 residues), see Phobius details amino acids 173 to 197 (25 residues), see Phobius details amino acids 254 to 273 (20 residues), see Phobius details amino acids 293 to 312 (20 residues), see Phobius details amino acids 319 to 338 (20 residues), see Phobius details amino acids 344 to 367 (24 residues), see Phobius details amino acids 386 to 406 (21 residues), see Phobius details amino acids 412 to 434 (23 residues), see Phobius details PF07690: MFS_1" amino acids 28 to 287 (260 residues), 124.5 bits, see alignment E=7.1e-40 amino acids 259 to 440 (182 residues), 79.7 bits, see alignment E=3e-26 PF00083: Sugar_tr" amino acids 29 to 264 (236 residues), 86.2 bits, see alignment E=3.5e-28 PF06779: MFS_4" amino acids 44 to 213 (170 residues), 42.3 bits, see alignment E=9.9e-15

Best Hits

Swiss-Prot: 86% identical to MHBT_KLEOX: 3-hydroxybenzoate transporter MhbT (mhbT) from Klebsiella oxytoca

KEGG orthology group: K08195, MFS transporter, AAHS family, 4-hydroxybenzoate transporter (inferred from 99% identity to ecw:EcE24377A_2434)

Predicted SEED Role

"4-hydroxybenzoate transporter" in subsystem Cinnamic Acid Degradation or Gentisare degradation or Phenylpropanoid compound degradation or Salicylate and gentisate catabolism or p-Hydroxybenzoate degradation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (452 amino acids)

>NIAGMN_21355 aromatic acid/H+ symport family MFS transporter (Escherichia coli ECRC102)
MTQRRDLQALIDAAPVGKMQWRVIICCFLVVMLDGFDTAAIGFIAPDIRTHWQLTAGDLA
PLFGAGLLGLTAGALLCGPLSDRFGRKRVIELCVFLFGALSLASAFSPDLQTLVFLRFLT
GLGLGGAMPNTITMTSEYLPARRRGALVTLMFCGFTLGSAFGGIVSAQLVPVIGWHGILV
LGGVLPLMLFVALLVVLPESPRWQVRRQLPQAVIAKTVSAITRERYVDTHFYLIESASVT
KGSIRQLFMGRQLPITLMLWVVFFMSLLIIYLLSSWMPTLLNHRGIDLQHASWVTAAFQI
GGTLGALALGVLMDKFNPFRVLTLSYAIGAICIVMIGLSQDGLWLMALAIFGTGIGISGS
QVGLNALTATLYPTQSRATGVSWSNAIGRCGAIVGSLSGGVMMAMNFSFDTLFFIIAVPA
AISAVMLTLLITVVRQSTSVPDSLPRAGVVNE