Protein Info for NIAGMN_06125 in Escherichia coli ECRC102

Name: copA
Annotation: copper-exporting P-type ATPase CopA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 834 transmembrane" amino acids 187 to 205 (19 residues), see Phobius details amino acids 217 to 238 (22 residues), see Phobius details amino acids 245 to 266 (22 residues), see Phobius details amino acids 284 to 302 (19 residues), see Phobius details amino acids 436 to 458 (23 residues), see Phobius details amino acids 464 to 486 (23 residues), see Phobius details amino acids 778 to 797 (20 residues), see Phobius details amino acids 803 to 824 (22 residues), see Phobius details PF00403: HMA" amino acids 8 to 62 (55 residues), 44.8 bits, see alignment 3.4e-15 amino acids 105 to 159 (55 residues), 59.7 bits, see alignment 7.4e-20 TIGR01511: copper-translocating P-type ATPase" amino acids 233 to 827 (595 residues), 642.2 bits, see alignment E=1.7e-196 TIGR01525: heavy metal translocating P-type ATPase" amino acids 252 to 827 (576 residues), 611.6 bits, see alignment E=3.4e-187 TIGR01494: HAD ATPase, P-type, family IC" amino acids 291 to 795 (505 residues), 299 bits, see alignment E=1e-92 PF00122: E1-E2_ATPase" amino acids 320 to 500 (181 residues), 183 bits, see alignment E=1e-57 PF00702: Hydrolase" amino acids 518 to 732 (215 residues), 137.5 bits, see alignment E=1.9e-43 PF08282: Hydrolase_3" amino acids 704 to 764 (61 residues), 25.5 bits, see alignment 2.6e-09

Best Hits

Swiss-Prot: 100% identical to COPA_ECO57: Copper-exporting P-type ATPase (copA) from Escherichia coli O157:H7

KEGG orthology group: K01533, Cu2+-exporting ATPase [EC: 3.6.3.4] (inferred from 100% identity to ecg:E2348C_0419)

Predicted SEED Role

"Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.3, EC 3.6.3.4, EC 3.6.3.5)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.3, 3.6.3.4, 3.6.3.5

Use Curated BLAST to search for 3.6.3.3 or 3.6.3.4 or 3.6.3.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (834 amino acids)

>NIAGMN_06125 copper-exporting P-type ATPase CopA (Escherichia coli ECRC102)
MSQTIDLTLDGLSCGHCVKRVKESLEQRPDVEQADVSITEAHVTGTASAEQLIETIKQAG
YDASVSHPKAKPLAESSIPSEALTAVSEALPAATADDDDSQQLLLSGMSCASCVTRVQNA
LQSVPGVTQARVNLAERTALVMGSASPQDLVQAVEKAGYGAEAIEDDAKRRERQQETAVA
TMKRFRWQAIVALAVGIPVMVWGMIGDNMMVTADNRSLWLVIGLITLAVMVFAGGHFYRS
AWKSLLNGAATMDTLVALGTGVAWLYSMSVNLWPQWFPMEARHLYYEASAMIIGLINLGH
MLEARARQRSSKALEKLLDLTPPTARLVTDEGEKSVPLAEVQPGMLLRLTTGDRVPVDGE
ITQGEAWLDEAMLTGEPIPQQKGEGDSVHAGTVVQDGSVLFRASAVGSHTTLSRIIRMVR
QAQSSKPEIGQLADKISAVFVPVVVVIALVSAAIWYFFGPAPQIVYTLVIATTVLIIACP
CALGLATPMSIISGVGRAAEFGVLVRDADALQRASTLDTVVFDKTGTLTEGKPQVVAVKT
FADFDEAQALRLAAALEQGSSHPLARAILDKASDMQLPQVNGFRTLRGLGVSGEAEGHAL
LLGNQALLNDQQVDTKAIEADISAQASQGATPVLLAVDGKAVALLAVRDPLRSDSVAALQ
RLHKAGYRLVMLTGDNPTTANAIAKEAGIDEVIAGVLPDGKAEAIKRLQSEGRQVAMVGD
GINDAPALAQADVGIAMGGGSDVAIETAAITLMRHSLMGVADALAISRATLRNMKQNLLG
AFIYNSIGIPVAAGILWPFTGTLLNPVVAGAAMALSSITVVSNANRLLRFKPKE