Protein Info for MPMX26_03097 in Acinetobacter radioresistens SK82

Annotation: Cobalt-zinc-cadmium resistance protein CzcA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1052 transmembrane" amino acids 26 to 48 (23 residues), see Phobius details amino acids 368 to 399 (32 residues), see Phobius details amino acids 413 to 435 (23 residues), see Phobius details amino acids 470 to 490 (21 residues), see Phobius details amino acids 501 to 526 (26 residues), see Phobius details amino acids 554 to 573 (20 residues), see Phobius details amino acids 892 to 911 (20 residues), see Phobius details amino acids 918 to 937 (20 residues), see Phobius details amino acids 944 to 968 (25 residues), see Phobius details amino acids 989 to 1009 (21 residues), see Phobius details amino acids 1020 to 1043 (24 residues), see Phobius details TIGR00914: heavy metal efflux pump, CzcA family" amino acids 20 to 1050 (1031 residues), 1460.9 bits, see alignment E=0 PF00873: ACR_tran" amino acids 24 to 1045 (1022 residues), 1054.4 bits, see alignment E=0

Best Hits

Swiss-Prot: 55% identical to HELA_LEGPN: Protein HelA (helA) from Legionella pneumophila

KEGG orthology group: K07239, heavy-metal exporter, HME family (inferred from 81% identity to abn:AB57_3666)

Predicted SEED Role

"Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1052 amino acids)

>MPMX26_03097 Cobalt-zinc-cadmium resistance protein CzcA (Acinetobacter radioresistens SK82)
MSTETPQIPDHESVKPEGLFDRLIQFSIHNAIWVMLFIAAWIAIGIYSYQKLPIDAVPDI
TNTQVQINTSANGFTALEMEQRITYPIENAMSGMPKMEQTRSISRYGLSQVTIIFEDGTD
IYWARQLINQRLQEAMGEMPEDVQPNMSPISTGLGEIYQWVIKAEPNAKKPDGTPYSAMD
LREIQDWIVRPQLQRVKGVAEINSIGGFNKTYVVAPDLNRLQQLQIPLSDLQTALTENNE
NRGAGYIEKNGQQLTVRVPGTLNTIEDIQNISIANKNGYPIRVADVANVSIGHDLRTGAA
TYNGEETVLGIAMMMMGENSRTVAQAIDEKVQSIQQSLPKGVVIETVYDRTHLVDRAIKT
VQKNLIEGAILVIVILFLFLGNFRAALITACVIPLSMLFTLTGMAEQKISANLMSLGALD
FGIIIDGAVVIVENCIRRLAEAQKLKGGLLSRSERFKEVFLAAKQARRPLIFGQLIILVV
YLPIFTLTGVEAKLFHPMAMTVVLALIGAMILSVTFVPAAVALFVTGEVKETESRWMHWL
KTKYELLLDKAYELRLFVTIVAACILVLTGVLATQTGSEFAPQLGEGDFAVQQMRSPSTG
LEQSLRMQENTEKLLLKEFPEIKAIFARTGTAEVATDVMPPNISDGVVLLKPHDEWPDPK
QTIDELRQRMITFLATLPGNNSEFSQPIELRFNELISGVRSDVGVKLFGDDMEILNREAN
KISQKINSISGATAVNVEQTSGLPLLNVEVDKSRAAQYGLSVRAIQDLVATSVGGQNVGT
ILQGDKRFDFVIRLDESQRSPEQLAVLPIQLPNGGLVQLQDVARVENILGINQVSRENGK
RRVVITANVEGRDLGSFVTELQSTLSKQELPSGYWIDYGGQFQNLMSAKARMQLVVPLAL
LTIFILLMAVFHNIKESLLVFSGVPFALCGGLIALWLRDIPLSMSAGVGFIALSGVAVLN
GLVMLTFIKELRQQYDLYYATWQGAILRLRPVLMTACVASLGFVPMALATGTGAEVQRPL
ATVVIGGIISSTLLTLVLLPVLYRWMNEKKVS