Protein Info for MPMX26_02924 in Acinetobacter radioresistens SK82
Annotation: Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: K00627, pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase) [EC: 2.3.1.12] (inferred from 71% identity to aby:ABAYE0158)Predicted SEED Role
"Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex (EC 2.3.1.12)" in subsystem Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate (EC 2.3.1.12)
MetaCyc Pathways
- superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass (20/26 steps found)
- pyruvate decarboxylation to acetyl CoA I (3/3 steps found)
- pyruvate fermentation to acetate II (3/3 steps found)
- photosynthetic 3-hydroxybutanoate biosynthesis (engineered) (19/26 steps found)
- superpathway of cytosolic glycolysis (plants), pyruvate dehydrogenase and TCA cycle (16/22 steps found)
- pyruvate fermentation to acetate and (S)-lactate I (3/4 steps found)
- pyruvate fermentation to acetate V (2/3 steps found)
- superpathway of anaerobic energy metabolism (invertebrates) (11/17 steps found)
- 1-butanol autotrophic biosynthesis (engineered) (18/27 steps found)
- anaerobic energy metabolism (invertebrates, mitochondrial) (5/10 steps found)
KEGG Metabolic Maps
- Biosynthesis of alkaloids derived from histidine and purine
- Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
- Biosynthesis of alkaloids derived from shikimate pathway
- Biosynthesis of alkaloids derived from terpenoid and polyketide
- Biosynthesis of phenylpropanoids
- Biosynthesis of plant hormones
- Biosynthesis of terpenoids and steroids
- Citrate cycle (TCA cycle)
- Glycolysis / Gluconeogenesis
- Pyruvate metabolism
Isozymes
Compare fitness of predicted isozymes for: 2.3.1.12
Use Curated BLAST to search for 2.3.1.12
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (679 amino acids)
>MPMX26_02924 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex (Acinetobacter radioresistens SK82) MQIKTPDIGVDQANVAEILVRVGDHIEVDDSIVVLESDKATVEVPATSAGVVKSILVNQG DDVTEGTALIELEAEGTSGGVTEAQEADAAQKTSENTPTELPDREIQQEISSYQPNSSTQ AAQPSESESSSAATVEVKLPDIGVEKALVGELLVQVGDDIQVDQSIAVVESDKATVEVPS TVAGKVQSITVKEGDSIKEGVVLITVRTAEGSAEPVSEKPSVQSATEKSASQQQAATSVE NSSSAESTEIEVTVPDLGVDKATVTEILVKVGDRVEAQQSLCVVESDKASVEIPSSAAGI IKALHVELNQVVKQGLLLAVVETEKSSEPVKTKQAAAVKEQDAATQQTVAKPQNDTGTLS APQQGTDKLSKEQQLENAKVYAGPAVRKLARELGVVLAQVKASGPHERVMKEDVFAYVKT RLTEVQKPASSTPAPVVSGLPALPDFTAFGGGELQTMTRLQQVSVPQLLLNNYIPQVTQF DLADITELEAWRGELKANFKKEGISLTILAFIAKAVAHLLKEEPYFAGHLADDQKAVMLR HEIHMGIAVATPDGLTVPVLRNPDQKSIRQIAQELGELSQKARDKKLSPKDLQGANFTIT SLGSIGGTAFTPLVNWPQVAILGISPATMQPVWNGESFDPRLMLPLSLSYDHRVINGADA ARFTNKLTKLLKDIRSLLL