Protein Info for MPMX26_02507 in Acinetobacter radioresistens SK82

Annotation: Succinyl-diaminopimelate desuccinylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01246: succinyl-diaminopimelate desuccinylase
  • amino acids 9 to 376 (368 residues), 560.8 bits, E=6.7e-173
• PF01546: Peptidase_M20
  • amino acids 65 to 373 (309 residues), 151.4 bits, E=3.2e-48
• PF07687: M20_dimer
  • amino acids 178 to 283 (106 residues), 92.6 bits, E=1.5e-30

Best Hits

Swiss-Prot: 85% identical to DAPE_ACIAD: Succinyl-diaminopimelate desuccinylase (dapE) from Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)

KEGG orthology group: K01439, succinyl-diaminopimelate desuccinylase [EC: 3.5.1.18] (inferred from 85% identity to aci:ACIAD0791)

MetaCyc: 57% identical to succinyl-diaminopimelate desuccinylase (Escherichia coli K-12 substr. MG1655)
Succinyl-diaminopimelate desuccinylase. [EC: 3.5.1.18]

Predicted SEED Role

"N-succinyl-L,L-diaminopimelate desuccinylase (EC 3.5.1.18)" in subsystem Arginine Biosynthesis extended or Lysine Biosynthesis DAP Pathway (EC 3.5.1.18)

MetaCyc Pathways

• aspartate superpathway (22/25 steps found)
• superpathway of L-lysine, L-threonine and L-methionine biosynthesis I (16/18 steps found)
• L-lysine biosynthesis I (9/9 steps found)

KEGG Metabolic Maps

• Lysine biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.5.1.18

Protein Sequence (378 amino acids)

>MPMX26_02507 Succinyl-diaminopimelate desuccinylase (Acinetobacter radioresistens SK82)
MTSSSDTLDLSLQLLRQPSVTPVDHNCQNIMAERLSKVGFHIENMRFEDVDNLWARRGTK
DPVFCFAGHTDVVPTGNLDAWNSDPFIPEIRDGKLYGRGSADMKTALAAMVIASERFVAK
HPDHKGSIAFLITSDEEGPSINGTVKVVETLESRNEKMTWCLVGEPSSTHQLGDIIKNGR
RGSLNGVLTVKGKQGHVAYPHLAINPIHTASAALAELCETVWDSGNEYFPATSFQISNIQ
AGTGATNVVPGTMTVTFNFRYSTEVTADELKARVITILQRHQVDFDIKWTLSGLPFLTPV
GELVNAAVQAIHEVNGVEAKLSTSGGTSDGRFIAPTGAQVLELGVLNASIHQIDEHVNVD
DLEPLAEIYEKILIQLLS