Protein Info for MPMX26_02311 in Acinetobacter radioresistens SK82

Annotation: Peptidoglycan D,D-transpeptidase MrdA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 670 transmembrane" amino acids 21 to 41 (21 residues), see Phobius details TIGR03423: penicillin-binding protein 2" amino acids 20 to 606 (587 residues), 726.5 bits, see alignment E=1.3e-222 PF03717: PBP_dimer" amino acids 64 to 234 (171 residues), 162.8 bits, see alignment E=1.2e-51 PF00905: Transpeptidase" amino acids 267 to 602 (336 residues), 228.1 bits, see alignment E=1.4e-71

Best Hits

KEGG orthology group: K05515, penicillin-binding protein 2 (inferred from 82% identity to aci:ACIAD1101)

Predicted SEED Role

"Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129)" in subsystem Bacterial Cell Division or Bacterial Cytoskeleton or Flagellum in Campylobacter or Peptidoglycan Biosynthesis (EC 2.4.1.129)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.4.1.129

Use Curated BLAST to search for 2.4.1.129

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (670 amino acids)

>MPMX26_02311 Peptidoglycan D,D-transpeptidase MrdA (Acinetobacter radioresistens SK82)
MKQHFPLKNEQQEKRIYRSRIFITMGIVAFFLLLLAGHYAYLQIAHYDEFSTASDKNRIR
LQPIAPARGYIYDRNGILLADNYPVFSATMSRADIEDIEATLARLTPVLSLTPEDIARFE
SRIKASRKTERVAIKMNLTETDIAKFSELKYQFPGVNIETQMTRYYPHGDLFAHVIGYVG
RINDKELKKIDKDLYAGTNLIGKIGVEKSYEELLHGIPGNESVEADAHGNVLRNLGRKDP
VRGNDLYLSIDYGLQMVATEQLAGRRGAIVALDPRTGEILALVSSPSFNPNLFVTGISHT
DYSGLRDNLDQPLYNRAVQGAYPPGSTIKPMFGLGGIHYGYVDWNTAISDPGYFTLPGDS
HRFRDHKKTGHGMVNLHKAQNVSCDTYFYVLSYRMGIEKMNTWMRQFGFGEKTGVDLPSE
SEGLYPNPEWKMRTRKAKWLKGETISVSIGQGAFTASPLQLALATAITANQGSRVTPHVL
RETRGTKTYHVHNGTNGKIQFNGTPEDWIKMREAMVDVIQTGTGKGIRSGLSYHIAGKTG
TAQVKSIAQGKRYNESLLTERQLDHGLFVGFAPAENPEIAIAVVWENGRHGGSAAQLARP
IFDYWLVKKEKNPIRPSAHQISGGLMTAGIKPAELPSGTTGIPAPETASGSNQPVVQSNM
ASRVQNVESD