Protein Info for MPMX26_02251 in Acinetobacter radioresistens SK82

Annotation: Succinylornithine transaminase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR03246: succinylornithine transaminase family
  • amino acids 6 to 400 (395 residues), 729.1 bits, E=1.3e-223
• TIGR00707: transaminase, acetylornithine/succinylornithine family
  • amino acids 14 to 398 (385 residues), 516.2 bits, E=4.6e-159
• PF00202: Aminotran_3
  • amino acids 24 to 398 (375 residues), 423.1 bits, E=9.5e-131
• PF00155: Aminotran_1_2
  • amino acids 169 to 326 (158 residues), 20.3 bits, E=2.9e-08

Best Hits

Swiss-Prot: 70% identical to ASTC_YERE8: Succinylornithine transaminase (astC) from Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)

KEGG orthology group: K00840, succinylornithine aminotransferase [EC: 2.6.1.81] (inferred from 83% identity to acd:AOLE_01800)

MetaCyc: 69% identical to succinylornithine transaminase (Escherichia coli K-12 substr. MG1655)
Succinylornithine transaminase. [EC: 2.6.1.81]; Acetylornithine transaminase. [EC: 2.6.1.81, 2.6.1.11]

Predicted SEED Role

"Succinylornithine transaminase (EC 2.6.1.81)" in subsystem Arginine and Ornithine Degradation (EC 2.6.1.81)

MetaCyc Pathways

• L-arginine biosynthesis II (acetyl cycle) (10/10 steps found)
• L-arginine biosynthesis I (via L-ornithine) (8/9 steps found)
• L-arginine degradation II (AST pathway) (5/5 steps found)
• L-arginine biosynthesis III (via N-acetyl-L-citrulline) (7/9 steps found)
• L-ornithine biosynthesis I (4/5 steps found)
• superpathway of arginine and polyamine biosynthesis (8/17 steps found)

KEGG Metabolic Maps

• Arginine and proline metabolism
• Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
• Lysine biosynthesis
• Urea cycle and metabolism of amino groups

Isozymes

Compare fitness of predicted isozymes for: 2.6.1.11

Use Curated BLAST to search for 2.6.1.11 or 2.6.1.81

Protein Sequence (401 amino acids)

>MPMX26_02251 Succinylornithine transaminase (Acinetobacter radioresistens SK82)
MNDVAITRSNFNDWMVPVFAPANFILVRGEGSRIWDQDDKEYIDFAGGIAVNALGHAHPV
AVNALTEQAQKLWHIGNGYTNEPVLRLAKQLVESTFADKVFFCNSGAEANEAALKLARKV
GLLSGNSEKNHIVAFKNAFHGRTLFTVTAGGQPKYSQDFAPLPGGIEHTAFNDLEAAKAL
ITENTCAVIVEPIQGEGGVLPADIEFLKGLRALCDEKGAVLIFDEVQTGVGRTGSLYAYM
NTGVTPDILTTAKALGGGFPIGAMITTDHYANMYAVGDHGTTYGGNPLACAVAGAVFEFI
NTPEVLDGVKQRHQYFIDALNKINAQYGLFKEIRGQGLLIGCVLKDEHAGKAKNIVTLAG
EEGLLALVAGADVVRFTPSLIIPQEDIDEGLNRFTRALARL