Protein Info for MPMX26_02183 in Acinetobacter radioresistens SK82

Annotation: Phosphoribosylformylglycinamidine synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1277 TIGR01735: phosphoribosylformylglycinamidine synthase" amino acids 5 to 1275 (1271 residues), 1840.8 bits, see alignment E=0 PF18076: FGAR-AT_N" amino acids 39 to 144 (106 residues), 102.1 bits, see alignment E=3.9e-33 PF18072: FGAR-AT_linker" amino acids 165 to 214 (50 residues), 79.3 bits, see alignment (E = 4.9e-26) PF02769: AIRS_C" amino acids 424 to 582 (159 residues), 122.9 bits, see alignment E=2.7e-39 amino acids 832 to 936 (105 residues), 34.1 bits, see alignment E=6.1e-12 PF13507: GATase_5" amino acids 1022 to 1276 (255 residues), 364.9 bits, see alignment E=3.9e-113

Best Hits

Swiss-Prot: 60% identical to PUR4_ECOL6: Phosphoribosylformylglycinamidine synthase (purL) from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

KEGG orthology group: K01952, phosphoribosylformylglycinamidine synthase [EC: 6.3.5.3] (inferred from 91% identity to aby:ABAYE0912)

MetaCyc: 59% identical to phosphoribosylformylglycinamide synthetase (Escherichia coli K-12 substr. MG1655)
Phosphoribosylformylglycinamidine synthase. [EC: 6.3.5.3]

Predicted SEED Role

"Phosphoribosylformylglycinamidine synthase, synthetase subunit (EC 6.3.5.3) / Phosphoribosylformylglycinamidine synthase, glutamine amidotransferase subunit (EC 6.3.5.3)" in subsystem De Novo Purine Biosynthesis (EC 6.3.5.3)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.3.5.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1277 amino acids)

>MPMX26_02183 Phosphoribosylformylglycinamidine synthase (Acinetobacter radioresistens SK82)
MFIVAGAPAHSSFKKTQLLSRLASISSVQSFDSQWVYLFDQALSEQQHQSALQLLNDGEI
FELRQVSDNEIQILVTPRVGTISPWSSKATDIFKNCNVPVHRLERGILYTLKDIPEVSAD
VKLALHDRMTESVFAQIEDAQALFNETAPKPLNSIDILGQGKEALVKANNEFGFALSDEE
IDYLTQAFTNMGRNPNDIELMMFAQANSEHCRHKIFGSEWTVDGEKQPLSLFQMIKNTYK
ESPTDVLSAYKDNASVIVGYDTQRFYPKQDESGHYVYKYKSQAAHILMKVETHNHPTAIS
PFAGAATGSGGEIRDEGATGRGGKPKAGLTGFTVSNLNIPGFEQPWEENYGKPSRMASPL
QIMIEGPLGGAAFNNEFGRPALNGYFRTFEQNVNGEVKGFHKPIMIAGGYGNIRPDHVEK
DAIQPGDLLIVLGGPAMLIGLGGGAASSVDSGTMGENLDFASVQRENPEMERRCQEVIDT
CWRLEDFNPIVSIHDVGAGGLSNAMPELVNDHELGAVLNLRKIPSLESGMSPMEIWSNEA
QERYVLAIRPESLQQFEEICARERCPFAVLGEATEARHLTVEDPLFANKPVDMPMQVMLG
GTPRMQRSYETAPRQGNDFDASKVDLNDAIFRVLKNPTVASKSFLITIGDRSITGMVARD
QMVGPWQVPVADAAVTTTSLQGYTGEAMAMGERPPVALLNPAASARLAVAEAITNIACAN
IEQISDIKLSANWMAAAGQKGEDQALFEGVKAIGMEMCPALGIAIPVGKDSLSMRTTWND
NGEDKAVTSPMTGVITAFAPVGDVRKTMTPELKKLEDSVLVRIDLSKGQFRLGGSILAQV
YKAIGTVTPDVDNFDEFKAFFALVQDWNNRGLIQAYHDIGDGGLLATVTEMMFASRLGVA
LEEQSVESLFAEEIGAVLQLKATDWEALQAEISESLLKDAISLIGSVNTTDTLNVNGLTL
ARSDLQQAWSEVSHQIQRLRDNVETADQEYSLITNADHQGIIAKPTFDLNEPIEAPFINT
RRPNMAILREQGVNGHVEMAAAFDKVGFNSIDVHMSDLLAGRVSLDEFEGLVTCGGFSYG
DVLGAGGGWAKSVLFNTKLRDQFEQFFHREETFSLGICNGCQMLSQLAPLIPGAENWPRF
HRNTSEVFEARTVNVRVEKSNSVVLEGMEGSILPIAVAHGEGRAVISDDSLSSLNANGQI
ALRYVDSHGNPTQQYPLNPNGSPEAVTGVTSRDGRATIMMPHPERTFRAIQHSWKPEEWK
EDGAWLRMFRNARKFIG