Protein Info for MPMX26_02020 in Acinetobacter radioresistens SK82

Annotation: 3-phosphoshikimate 1-carboxyvinyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF03446: NAD_binding_2
  • amino acids 8 to 105 (98 residues), 31.2 bits, E=5.3e-11
• PF03807: F420_oxidored
  • amino acids 8 to 98 (91 residues), 42 bits, E=3.1e-14
• PF02153: PDH_N
  • amino acids 23 to 177 (155 residues), 112.3 bits, E=3.8e-36
• PF20463: PDH_C
  • amino acids 182 to 278 (97 residues), 98.9 bits, E=4.7e-32
• PF00275: EPSP_synthase
  • amino acids 313 to 735 (423 residues), 395.4 bits, E=7.1e-122
• TIGR01356: 3-phosphoshikimate 1-carboxyvinyltransferase
  • amino acids 318 to 739 (422 residues), 432.2 bits, E=9.5e-134

Best Hits

KEGG orthology group: K00220, cyclohexadieny/prephenate dehydrogenase [EC: 1.3.1.12 1.3.1.43] K00800, 3-phosphoshikimate 1-carboxyvinyltransferase [EC: 2.5.1.19] (inferred from 90% identity to acd:AOLE_05655)

Predicted SEED Role

"Cyclohexadienyl dehydrogenase (EC 1.3.1.12)(EC 1.3.1.43) / 5-Enolpyruvylshikimate-3-phosphate synthase (EC 2.5.1.19)" in subsystem Chorismate Synthesis or Common Pathway For Synthesis of Aromatic Compounds (DAHP synthase to chorismate) or Phenylalanine and Tyrosine Branches from Chorismate (EC 1.3.1.12, EC 1.3.1.43, EC 2.5.1.19)

MetaCyc Pathways

• superpathway of aromatic amino acid biosynthesis (18/18 steps found)
• superpathway of L-tryptophan biosynthesis (13/13 steps found)
• superpathway of L-phenylalanine biosynthesis (10/10 steps found)
• superpathway of L-tyrosine biosynthesis (10/10 steps found)
• chorismate biosynthesis I (7/7 steps found)
• chorismate biosynthesis from 3-dehydroquinate (5/5 steps found)
• L-tyrosine biosynthesis I (3/3 steps found)
• L-tyrosine biosynthesis III (3/4 steps found)
• chorismate biosynthesis II (archaea) (8/12 steps found)
• 4-hydroxy-3-prenylbenzoate biosynthesis (1/4 steps found)
• superpathway of chorismate metabolism (36/59 steps found)
• superpathway of novobiocin biosynthesis (4/19 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from shikimate pathway
• Biosynthesis of phenylpropanoids
• Biosynthesis of plant hormones
• Novobiocin biosynthesis
• Phenylalanine, tyrosine and tryptophan biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.3.1.12 or 1.3.1.43 or 2.5.1.19

Protein Sequence (748 amino acids)

>MPMX26_02020 3-phosphoshikimate 1-carboxyvinyltransferase (Acinetobacter radioresistens SK82)
MSQPLFEKVAFIGLGLIGSSLARVIVAQKLARHVVAATRSQKTLEDAKALGLIEQGYSDP
VEAVQGADLIVLALPVRATQKILEHIKPHICAHTILTDVGSTKGNVVEAAKAVYGTHLPP
GFVPGHPIAGSEHTGVHAGKVDLFANHKVILTPLPSSASWAVDKLIELWEAAQAEVICMD
VEKHDEVLAHTSHLPHLMAFNLVEQLASREDNLDIFRYAAGGFRDFSRVAASDPQMWHDI
FFANKKAILNAVDGFEQQLGIIRKMIENEDSQALMGLLGHAQAARQHFNHMLAQKPLMEK
NKVTQQFTILPGNKTFQGKFTVPGDKSVSHRSIMFGAIAEGTTHVTGFLEGEDALATLQA
FRDMGVSIEGPKNGEVTIHGVGMHGLKAPASALYMGNSGTSMRLLSGMLAAQKFDTVMTG
DASLSKRPMERIAKPLRLMGAQIQTTGEKGTPPVSISGQQKLHGIHYDLPMPSAQVKSGI
LLAGLWAEGETSVTEPEPTRDHTERMLRAFGYEVKTEGHKISLIGGGKLVGTEIQVPSDI
SSAAFFMVGAAITQNSDVLLEAVGINPTRTGIIEILKQMGADLTVENERIAGGEPIADIH
IRGSRTLKGIHIPEDQVPLAIDEFPALFVAAACAEGQTVLTGAAELRVKESDRIQVMADG
LKTMGIDCTPTEDGIIIEGKGKIGDWSAVFTGGEIESHHDHRIAMSFSMAGLRSSGTINI
MGTETVATSFPTFTELANKAGLAIQVSE