Protein Info for MPMX26_01948 in Acinetobacter radioresistens SK82

Annotation: Copper-transporting P-type ATPase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 825 transmembrane" amino acids 168 to 191 (24 residues), see Phobius details amino acids 203 to 220 (18 residues), see Phobius details amino acids 240 to 260 (21 residues), see Phobius details amino acids 270 to 288 (19 residues), see Phobius details amino acids 422 to 444 (23 residues), see Phobius details amino acids 450 to 473 (24 residues), see Phobius details amino acids 766 to 785 (20 residues), see Phobius details amino acids 791 to 813 (23 residues), see Phobius details TIGR00003: copper ion binding protein" amino acids 13 to 75 (63 residues), 43.8 bits, see alignment 5.7e-15 amino acids 81 to 143 (63 residues), 41.8 bits, see alignment 2.5e-14 PF00403: HMA" amino acids 14 to 74 (61 residues), 62 bits, see alignment 1.1e-20 amino acids 83 to 142 (60 residues), 61.2 bits, see alignment 2e-20 TIGR01511: copper-translocating P-type ATPase" amino acids 220 to 816 (597 residues), 605.5 bits, see alignment E=2.7e-185 TIGR01525: heavy metal translocating P-type ATPase" amino acids 238 to 815 (578 residues), 636.1 bits, see alignment E=1.6e-194 TIGR01494: HAD ATPase, P-type, family IC" amino acids 277 to 784 (508 residues), 317.7 bits, see alignment E=2.7e-98 PF00122: E1-E2_ATPase" amino acids 306 to 486 (181 residues), 201.6 bits, see alignment E=1.6e-63 PF00702: Hydrolase" amino acids 503 to 720 (218 residues), 138.6 bits, see alignment E=7e-44 PF08282: Hydrolase_3" amino acids 695 to 752 (58 residues), 22 bits, see alignment 2.4e-08

Best Hits

Swiss-Prot: 61% identical to ATCU_SINMW: Copper-transporting P-type ATPase (actP) from Sinorhizobium medicae (strain WSM419)

KEGG orthology group: K01533, Cu2+-exporting ATPase [EC: 3.6.3.4] (inferred from 81% identity to abb:ABBFA_002361)

Predicted SEED Role

"Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.3, EC 3.6.3.4, EC 3.6.3.5)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.3, 3.6.3.4, 3.6.3.5

Use Curated BLAST to search for 3.6.3.3 or 3.6.3.4 or 3.6.3.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (825 amino acids)

>MPMX26_01948 Copper-transporting P-type ATPase (Acinetobacter radioresistens SK82)
MDSKNIKPSPYRETLFITGMTCASCVGRVEKALKKVEGVESAQVNLATEKAVVSSSEPLD
LMVLTKAVERAGYEVSATQPIELEIDGMTCASCVARVEKALKKVTGVQQANVNLATERAW
VQGNTQLQINDLIQAVQKAGYTAKLAEQDQNEQQGKKASEQQQLKRDLILSLILALPVFI
LEMGSHMIPAFHMWVMEYIGHQPNWLIQFVLTTLVLIFPGRRFYQKGIPALFRLAPDMNS
LVAVGTLAAYSFSLVATFIPEILPQGTVHVYYEAAAVIVSLILLGRYLEAKAKGRTSQAI
QHLIGMQAKTARIYRDGQVIEVPVAEVTTDTIVEIRPGERVPVDGEVVEGRSYIDESMIT
GEPVPVEKHSGDQVVGGTINQNGTLNIRATAIGESSVLAQIIRMVEQAQGSKLPIQMLVD
KVTMWFVPMVMLLATLTFIVWFLFGPEPALTFSLVNAVAVLIIACPCAMGLATPTSIMVG
TGRGAEMGVLFRKGEALQLLQEVKVVAVDKTGTLTEGRPLLTDFHVQQGFEHKKVLQIVA
SVEAKSEHPIALAIVQATEQQEINLLPVTAFDSVTGSGIKAEVEGQSVQIGADRYMQQLG
LNVTSFEQEAARLGQEGKTPIYVAINHELAAIIAVADPIKETTYAAINALHQLGLKVAMI
TGDNRHTAQAIAARLHIDQVVAEVLPDGKVEVVRQLQQQYGRVAFVGDGINDAPALAQAD
VGLAIGTGTDVAIEAAEVILMSGNLQGVPNAIALSKATISNIRQNLFWAFVYNIALIPIA
AGVLYPAFGILLSPIFAAGAMALSSVFVLGNALRLKYFNALQIST