Protein Info for MPMX26_01469 in Acinetobacter radioresistens SK82

Annotation: Aspartate ammonia-lyase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00839: aspartate ammonia-lyase
  • amino acids 10 to 470 (461 residues), 691.5 bits, E=3.2e-212
• PF00206: Lyase_1
  • amino acids 19 to 350 (332 residues), 309.8 bits, E=2.5e-96
• PF10415: FumaraseC_C
  • amino acids 416 to 468 (53 residues), 51.7 bits, 9.9e-18

Best Hits

Swiss-Prot: 59% identical to ASPA_ECOLI: Aspartate ammonia-lyase (aspA) from Escherichia coli (strain K12)

KEGG orthology group: K01744, aspartate ammonia-lyase [EC: 4.3.1.1] (inferred from 62% identity to bba:Bd2857)

MetaCyc: 59% identical to aspartate ammonia-lyase (Escherichia coli K-12 substr. MG1655)
Aspartate ammonia-lyase. [EC: 4.3.1.1]

Predicted SEED Role

"Aspartate ammonia-lyase (EC 4.3.1.1)" in subsystem Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis (EC 4.3.1.1)

MetaCyc Pathways

• L-glutamate degradation II (2/2 steps found)
• superpathway of L-aspartate and L-asparagine biosynthesis (3/4 steps found)
• L-aspartate degradation II (aerobic) (2/3 steps found)
• L-aspartate degradation III (anaerobic) (2/3 steps found)
• L-canavanine degradation II (1/6 steps found)

KEGG Metabolic Maps

• Alanine and aspartate metabolism
• Nitrogen metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.3.1.1

Protein Sequence (484 amino acids)

>MPMX26_01469 Aspartate ammonia-lyase (Acinetobacter radioresistens SK82)
MNIGQNNRFRTEKDLLGTKEVLSSSYYGIHTLRALENFQISQQKIGEQHHFIRALAQVKK
ASAQANQFFGKLTEQQSQAIQAACQKLIDTPENWEKHFPLDVYQGGAGTSINMNTNEVIA
NLALEMTGHDKGSYYIIHPNDHVNKSQSTNDVYPTALRVATYYALDQLFMQVKSLITSLE
YKATEFRFVLKMGRTQLQDAVPMTLGQEFRAFATLLKEDVRLIQKMRQLLLEINLGATAI
GTGVNTPQGYAAKVVECLKEITGLPLSGAEDYVEATSDCGVFIILSSSLKRLACKLSKIC
NDLRLLSSGPRTGLAEISLPEMQAGSSIMPAKVNPVIPEVVNQIAFKVIGNDLTITFAAE
AGQLQLNVMEPVIAQALNESIGLLTQGIKTLDEKCIQGIHANEKTCYEAVMRSVGIITLL
EPILGHGACYEIGKQCIAENRTIQDVVLEKKLLTEKQLEEIFSFENLVSEVLSGSASQTL
DQVS