Protein Info for MPMX26_01158 in Acinetobacter radioresistens SK82

Annotation: Protoheme IX farnesyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 292 transmembrane" amino acids 12 to 29 (18 residues), see Phobius details amino acids 35 to 59 (25 residues), see Phobius details amino acids 80 to 102 (23 residues), see Phobius details amino acids 108 to 126 (19 residues), see Phobius details amino acids 136 to 153 (18 residues), see Phobius details amino acids 159 to 179 (21 residues), see Phobius details amino acids 208 to 225 (18 residues), see Phobius details amino acids 231 to 251 (21 residues), see Phobius details amino acids 263 to 283 (21 residues), see Phobius details TIGR01473: protoheme IX farnesyltransferase" amino acids 3 to 277 (275 residues), 270.2 bits, see alignment E=1.4e-84 PF01040: UbiA" amino acids 18 to 267 (250 residues), 197.5 bits, see alignment E=1.2e-62

Best Hits

Swiss-Prot: 79% identical to CYOE_ACIBS: Protoheme IX farnesyltransferase (cyoE) from Acinetobacter baumannii (strain SDF)

KEGG orthology group: K02301, protoheme IX farnesyltransferase [EC: 2.5.1.-] (inferred from 79% identity to acd:AOLE_06305)

MetaCyc: 51% identical to heme O synthase (Escherichia coli K-12 substr. MG1655)
HEMEOSYN-RXN [EC: 2.5.1.141]

Predicted SEED Role

No annotation

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.5.1.-

Use Curated BLAST to search for 2.5.1.- or 2.5.1.141

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (292 amino acids)

>MPMX26_01158 Protoheme IX farnesyltransferase (Acinetobacter radioresistens SK82)
MLKKYLFLTKPGILFGNFITTLGGFLLAAQGSVDFLLLFLTLIGTTLVVASGCVVNNIID
QDIDQKMQRTQNRALVKKTVSVPVAMLYALVLGVIGFSILWFWVNTYAFAFAVVGFVVYV
GFYSLWTKRTSIHQTLIGSISGASPPVIGYTAVTNEFDLAALLIFAGYAFWQMPHSWGIA
IYRFDDYKNAGIPILPVARSILRTKIESLIYIVLFSIAMNALFIYGYTNWLYLVILNLLC
IYWFYIGLIGLKAENDQLWAKRFFLFSVTLITIVSLSFSFTSVSPAPHFPIF