Protein Info for MPMX26_01140 in Acinetobacter radioresistens SK82

Annotation: Phosphoribosylamine--glycine ligase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 427 TIGR00877: phosphoribosylamine--glycine ligase" amino acids 1 to 422 (422 residues), 590.2 bits, see alignment E=1.1e-181 PF02844: GARS_N" amino acids 1 to 102 (102 residues), 129 bits, see alignment E=2.7e-41 PF01071: GARS_A" amino acids 103 to 296 (194 residues), 286.6 bits, see alignment E=2.6e-89 PF02786: CPSase_L_D2" amino acids 108 to 192 (85 residues), 21.9 bits, see alignment E=2.7e-08 PF02843: GARS_C" amino acids 330 to 420 (91 residues), 106.7 bits, see alignment E=1.6e-34

Best Hits

Swiss-Prot: 68% identical to PUR2_PSEAE: Phosphoribosylamine--glycine ligase (purD) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

KEGG orthology group: K01945, phosphoribosylamine--glycine ligase [EC: 6.3.4.13] (inferred from 85% identity to acb:A1S_2189)

MetaCyc: 65% identical to phosphoribosylamine--glycine ligase (Escherichia coli K-12 substr. MG1655)
Phosphoribosylamine--glycine ligase. [EC: 6.3.4.13]

Predicted SEED Role

"Phosphoribosylamine--glycine ligase (EC 6.3.4.13)" in subsystem De Novo Purine Biosynthesis (EC 6.3.4.13)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.3.4.13

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (427 amino acids)

>MPMX26_01140 Phosphoribosylamine--glycine ligase (Acinetobacter radioresistens SK82)
MNILVLGSGGREHALAWKIAQDDQVAQVFVAPGNAGTATENKCENVALDILDNPAIIDFV
KNNAIDLIIVGPEAPLVNGVVDACREAGVKIWGPTQFAAQLEGSKAFAKHFLKRHNIPTA
FYDVFTEVDAAKAFVEKNGAPIVIKADGLAAGKGVIVAMTNEEAFAAIDDMLAGNKFGDA
GSRVVIEEFLAGEEASFICMIDGDNILPMATSQDHKRIFEGDQGPNTGGMGAYSPAPVVT
VDVFEKTMNEVMRPTVEGMKKDGHVYTGFLYAGLMIDEQGQPKVIEFNCRFGDPETQPIM
MRLKSSLVDLVQAGIEGNLPSEAEWDERKTVGIVLASKGYPETSSSGDVISGLNTEMTDA
KVFHAGTKANENGEIVTAGGRVLCVTALGNTIGEAQAKALELCQKVTFNGVQYRKDIGYR
AIAREQG