Protein Info for MPMX26_01120 in Acinetobacter radioresistens SK82

Annotation: Dihydroorotate dehydrogenase (quinone)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01036: dihydroorotate dehydrogenase (fumarate)
  • amino acids 3 to 332 (330 residues), 427.5 bits, E=1.6e-132
• PF01180: DHO_dh
  • amino acids 44 to 331 (288 residues), 247.9 bits, E=6.3e-78

Best Hits

Swiss-Prot: 82% identical to PYRD_ACIBC: Dihydroorotate dehydrogenase (quinone) (pyrD) from Acinetobacter baumannii (strain ACICU)

KEGG orthology group: K00226, dihydroorotate dehydrogenase (fumarate) [EC: 1.3.98.1] (inferred from 83% identity to acd:AOLE_05785)

MetaCyc: 58% identical to dihydroorotate dehydrogenase, type 2 (Escherichia coli K-12 substr. MG1655)
Dihydroorotate dehydrogenase. [EC: 1.3.5.2]; 1.3.5.2 [EC: 1.3.5.2]; 1.3.5.2 [EC: 1.3.5.2]

Predicted SEED Role

"Dihydroorotate dehydrogenase (EC 1.3.3.1)" in subsystem De Novo Pyrimidine Synthesis (EC 1.3.3.1)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (43/46 steps found)
• superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (18/18 steps found)
• superpathway of pyrimidine ribonucleotides de novo biosynthesis (9/9 steps found)
• UMP biosynthesis I (6/6 steps found)
• UMP biosynthesis II (6/6 steps found)

KEGG Metabolic Maps

• Pyrimidine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.3.3.1 or 1.3.5.2 or 1.3.98.1

Protein Sequence (334 amino acids)

>MPMX26_01120 Dihydroorotate dehydrogenase (quinone) (Acinetobacter radioresistens SK82)
MFYSLARPLLFSLAPERAHELTLSLLKSAHKFGIGHQTVAHKPVTCMGIEFPNPVGLAAG
LDKNGAYIDALAALGFGFIEIGTVTPRPQSGNPQPRLFRIPEAKAIINRMGFNNDGVDRL
VENVKAAKYKGILGINIGKNADTPVENAVSDYLTCLEKVYNYASYVTVNISSPNTKNLRD
LQSGHALTELLKTLKNRQLELAEQYQHYVPLVLKVAPDLSQQDIEFIASQLVIFKIDGLI
VTNTTLSREGVEGLACADESGGLSGAPVFEKSNQCLQEFAKRLKGQVALVGVGGIVSGNQ
AAVKQQYGAQLVQIYSGLIYTGPNLIKDCVDAMN