Protein Info for MPMX26_01003 in Acinetobacter radioresistens SK82

Annotation: Adenosylhomocysteinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF05221: AdoHcyase
  • amino acids 10 to 147 (138 residues), 246.9 bits, E=4e-77
  • amino acids 147 to 459 (313 residues), 170 bits, E=1.1e-53
• TIGR00936: adenosylhomocysteinase
  • amino acids 11 to 452 (442 residues), 523.3 bits, E=2.1e-161
• PF00670: AdoHcyase_NAD
  • amino acids 197 to 372 (176 residues), 193.4 bits, E=4.5e-61

Best Hits

Swiss-Prot: 94% identical to SAHH_ACIAD: Adenosylhomocysteinase (ahcY) from Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)

KEGG orthology group: K01251, adenosylhomocysteinase [EC: 3.3.1.1] (inferred from 93% identity to acd:AOLE_05345)

Predicted SEED Role

"Adenosylhomocysteinase (EC 3.3.1.1)" in subsystem Methionine Biosynthesis or Methionine Degradation (EC 3.3.1.1)

MetaCyc Pathways

• S-adenosyl-L-methionine salvage II (3/3 steps found)
• L-methionine degradation I (to L-homocysteine) (2/3 steps found)
• superpathway of L-cysteine biosynthesis (mammalian) (2/5 steps found)
• superpathway of L-methionine salvage and degradation (5/16 steps found)

KEGG Metabolic Maps

• Methionine metabolism
• Selenoamino acid metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.3.1.1

Protein Sequence (460 amino acids)

>MPMX26_01003 Adenosylhomocysteinase (Acinetobacter radioresistens SK82)
MNAVTASFTDYKVADISLADYGRKEIKLAEAEMPALMGLRKRYSAAKPLAGAKILGCIHM
TIQTAVLIETLVELGAEVRWTSCNIFSTQDHAAAAIAASGIPVFAWKGETEEEYMWCLEQ
QINVNGKPWDANMILDDGGDLTAVVHEKYPELIAKIHGITEETTTGVARLLEMWKDGSLK
VPAINVNDSVTKSKNDNKYGCRHSLNDAIKRATDMLLSGRRALVIGYGDVGKGSAQSLRQ
EGMIVRVTEVDPICAMQACMDGYEVVSPYKNGVQTGNKEDINVDLLKNTDLIVTTTGNYH
VCDAAMLDTLKAGAVVCNIGHFDTEIDTAYLRGYKWVEVKPQVHQVYRSENENDYLLLLS
EGRLVNLGNATGHPSRVMDGSFANQVLGQMHLFAEKFADLPEDQKQAKIRVELLPKKLDE
EVAAAMVAGFGGVLTQLTTEQATYLGVPVEGPFKSDAYKY