Protein Info for MPMX26_00689 in Acinetobacter radioresistens SK82

Annotation: Multidrug resistance protein MexB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1059 signal peptide" amino acids 1 to 11 (11 residues), see Phobius details amino acids 27 to 27 (1 residues), see Phobius details transmembrane" amino acids 12 to 26 (15 residues), see Phobius details amino acids 340 to 359 (20 residues), see Phobius details amino acids 366 to 388 (23 residues), see Phobius details amino acids 394 to 413 (20 residues), see Phobius details amino acids 440 to 460 (21 residues), see Phobius details amino acids 471 to 497 (27 residues), see Phobius details amino acids 539 to 558 (20 residues), see Phobius details amino acids 879 to 898 (20 residues), see Phobius details amino acids 905 to 926 (22 residues), see Phobius details amino acids 938 to 959 (22 residues), see Phobius details amino acids 986 to 1007 (22 residues), see Phobius details amino acids 1015 to 1041 (27 residues), see Phobius details TIGR00915: RND transporter, hydrophobe/amphiphile efflux-1 (HAE1) family" amino acids 1 to 1056 (1056 residues), 1595.9 bits, see alignment E=0 PF00873: ACR_tran" amino acids 1 to 1041 (1041 residues), 1255.4 bits, see alignment E=0 PF03176: MMPL" amino acids 283 to 512 (230 residues), 26.9 bits, see alignment E=2.3e-10

Best Hits

KEGG orthology group: K03296, hydrophobic/amphiphilic exporter-1 (mainly G- bacteria), HAE1 family (inferred from 84% identity to acd:AOLE_03530)

Predicted SEED Role

"RND efflux system, inner membrane transporter CmeB" in subsystem Multidrug Resistance Efflux Pumps or Multidrug efflux pump in Campylobacter jejuni (CmeABC operon)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1059 amino acids)

>MPMX26_00689 Multidrug resistance protein MexB (Acinetobacter radioresistens SK82)
MAQFFIHRPIFAWVIALVIMLAGVLTLTKMPIAQYPTIAPPTVTIAATYPGASAETVENT
VTQIIEQQMNGLDGLRYISSSSAGNGQASIQLNFEQGIDPDIAQVQVQNKLQSATALLPE
DVQRQGVRVTKSGASFLQVIAFYSPDDSLSDADIKDYVNSNISEPLSRVAGVGEVQVFGG
SYAMRIWLDPAKLSSFQLTPSDVANAIRSQNAQVAVGQLGGAPLTKDQVLNATVTAQSLL
QTPEEFSNVFLKNTASGAQVRIGDVAKVELGSADYGFISKYNNKPAAGVAIKLATGANAL
DTAEAVEARLKELRTSYPQGMVDVLAFDTTPFIKLSIESVVHTLVEAVILVFIVMFLFLQ
NWRATIIPTLAVPVVVLGTFAVINIFGFSINTLTMFAMVLAIGLLVDDAIVVVENVERVM
AEEHLDPVTATELSMKQISGALIGITSVLTAVFVPMAFFGGTTGVIYRQFSITLVTAMIL
SLIVALTFTPALCATLLKQHDPNKAPSNNIFARFFRWFNHKFDRMSHRYQNGVSKLLHHR
IISGVFYVVVIGILVLLFQKLPSSFLPDEDQGVVMTLVQLPPNASLSRTEQVVDTMTGFF
LENEKEYVQSVFSVAGFSFTGVGQNAGLAFIRLKDWSERTTPEAQIGAIIQRGMALNVIA
KDASYVMPLQLPAMPELGVTAGFSFMLKDAGGNGHEKLMAARNAILGMAAQDPRLMGVRP
NGQEDTPQYKISIDQAQAGAMGVSIADINSTMSIAWGGSYINDFVDRGRVKRVYVQGQAD
TRMMPEDLDKWYVRNNQGQMVPFSAFATGEWTYGSPRLERYNGISSVNIQGTPAPGVSSG
DAMLAMQEIMAKLPSMGMQGYDYEWSGLSLEENEAGSQTAALLALSILIVFLCLAALYES
WSIPFSVLMVIPLGIVGAVILTFLGMMISKDPNLSNNIYFKVAIIAVIGLAAKNAILIVE
FAKDLQEEGEELLEATLHAARMRLRPIIMTTLAFGFGVLPLALSSGAGAGSQHSVGYGVL
GGVISSTLLGIFFIPVFYVWIRSIFKQKPKNRNNQEQIS