Protein Info for MPMX26_00535 in Acinetobacter radioresistens SK82

Annotation: Signal transduction histidine-protein kinase BarA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 934 transmembrane" amino acids 21 to 41 (21 residues), see Phobius details amino acids 170 to 194 (25 residues), see Phobius details PF00512: HisKA" amino acids 289 to 354 (66 residues), 74.4 bits, see alignment 1.3e-24 PF02518: HATPase_c" amino acids 401 to 517 (117 residues), 82.5 bits, see alignment E=5.9e-27 PF00072: Response_reg" amino acids 666 to 787 (122 residues), 78.8 bits, see alignment E=6.9e-26 PF01627: Hpt" amino acids 833 to 918 (86 residues), 43.6 bits, see alignment E=5.7e-15

Best Hits

KEGG orthology group: K07678, two-component system, NarL family, sensor histidine kinase BarA [EC: 2.7.13.3] (inferred from 79% identity to aby:ABAYE3185)

Predicted SEED Role

"BarA sensory histidine kinase (= VarS = GacS)" in subsystem Type III secretion system orphans

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3

Use Curated BLAST to search for 2.7.13.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (934 amino acids)

>MPMX26_00535 Signal transduction histidine-protein kinase BarA (Acinetobacter radioresistens SK82)
MSNLNKKLSKRLHLNHAYGQLIALIFVPIMVLACVGAALVLTETSNAAKAQQRHTATAIL
TRYEHVAQQLFYLLSQNPDRYTQARNILQYMFIEQHLQGAMIIDKNGKSYLDIGFQSEPS
QIKPPQNSIFFGPVSYHHNHLYGLQISSDPANKAWLVIEMDNQPLEIARYRVMIVLIATG
LLTLLLLLLCLNFYSRRWIAPMYEIRMQLQRLNVDTLDQHIIINSTGELRLLQRDIANVV
KRLHFSFLELKEHTEQTEDDLRRTLDTLEVQNITYRQARDQAISANQAKSVFLANISHEL
RTPLNSIDGFIHLMLRQDNLSNEQNLYLQTIRKSSAHLLALINDVLDFSKIDAGKLELET
APFDLEEAIFDVMDMLSPLAAQKQIDMAFYYGDDVPQYIVGDVLRFKQILTNLISNAIKF
TPDGEIIVRARMEQDGMEQCLLHFSVQDSGIGLSGTDRKKLFESFSQGDTSVTRQFGGTG
LGLAISKQLVHLMQGQIGFEDNQERAPTEKGSTFWFTAMFGVEDEHEQQHPNFEHIHVLS
FLAHPATANVLRHYLENYQVKHTETQSILDLFSRLNQLKDQSENTWLIVDHSGDSEALLK
EIRSRYSGHLAVYGYQMVLEPNILTEYRARPLYQPLSRTALIQLLSNQPVFEQDSLESFN
GRGLHILAVDDHLPNLIVLEALLGELNVTTTKALSGQEALDILHHQIERKEKLFDLIFMD
IQMPVMSGIDTTRAIRSLESTLEGEVHLPIIALTAHALADEKNKLLKVGMDDYVTKPIQI
DQLIHILTQWTNNQFNQPPAIESGILLDALDPEVLDWQQSLQLAANKEDLAHDLLKMLVD
SFPAELAEMQQLIELEDFPQLEHVLHRLYGATRYVGTPKLQETSGSFEQFVSTLRKECRK
ADEAFIQETLNRFDELTAIIHEVETAARHILDAS