Protein Info for MPMX26_00451 in Acinetobacter radioresistens SK82

Annotation: dTDP-4-dehydrorhamnose reductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 297 PF04321: RmlD_sub_bind" amino acids 1 to 294 (294 residues), 354.9 bits, see alignment E=7.1e-110 TIGR01214: dTDP-4-dehydrorhamnose reductase" amino acids 2 to 291 (290 residues), 329.8 bits, see alignment E=6.1e-103 PF01370: Epimerase" amino acids 3 to 179 (177 residues), 57.4 bits, see alignment E=3.8e-19 PF16363: GDP_Man_Dehyd" amino acids 37 to 142 (106 residues), 31.5 bits, see alignment E=3.4e-11 PF02719: Polysacc_synt_2" amino acids 38 to 146 (109 residues), 23.1 bits, see alignment E=1e-08 PF07993: NAD_binding_4" amino acids 53 to 158 (106 residues), 21.3 bits, see alignment E=3.4e-08

Best Hits

Swiss-Prot: 58% identical to RMLD_ECOLI: dTDP-4-dehydrorhamnose reductase (rfbD) from Escherichia coli (strain K12)

KEGG orthology group: K00067, dTDP-4-dehydrorhamnose reductase [EC: 1.1.1.133] (inferred from 59% identity to pfo:Pfl01_4057)

Predicted SEED Role

"dTDP-4-dehydrorhamnose reductase (EC 1.1.1.133)" in subsystem Rhamnose containing glycans or dTDP-rhamnose synthesis or linker unit-arabinogalactan synthesis (EC 1.1.1.133)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.133

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (297 amino acids)

>MPMX26_00451 dTDP-4-dehydrorhamnose reductase (Acinetobacter radioresistens SK82)
MKILLLGKNGQVGWELQRALAPLGEVVALDRHGLNGLSGDMTQPSAIFDTIVALKPDVVV
NASAYTAVDLAETEQDSADLVNHQTVKAIADACLQIKALFVHYSTDYVFDGAGETAFVET
DAIAPLNVYGKTKALGEQAIVESGCQHLIFRTSWVYASKGKNFLKTMLNLAQQREELSII
DDQIGAPTSAELIADITAHAIPQVVADVSKAGVYHLVASGETSWFGYASYVFEQARSLGQ
ALIVQKVNPIPTKAYPTPATRPHNSRLNNQKIQHVFKLCLPNWQDGVKRTIVELLNK