Protein Info for MPMX26_00409 in Acinetobacter radioresistens SK82

Annotation: ATP-dependent Clp protease ATP-binding subunit ClpX

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 438 TIGR00382: ATP-dependent Clp protease, ATP-binding subunit ClpX" amino acids 5 to 409 (405 residues), 679.5 bits, see alignment E=8.9e-209 PF06689: zf-C4_ClpX" amino acids 9 to 45 (37 residues), 62.2 bits, see alignment 1.2e-20 PF01078: Mg_chelatase" amino acids 109 to 137 (29 residues), 20.6 bits, see alignment (E = 9e-08) PF07724: AAA_2" amino acids 112 to 310 (199 residues), 121.4 bits, see alignment E=1.4e-38 PF07728: AAA_5" amino acids 114 to 191 (78 residues), 27.8 bits, see alignment E=8.2e-10 PF00004: AAA" amino acids 115 to 243 (129 residues), 61.4 bits, see alignment E=4.6e-20 PF10431: ClpB_D2-small" amino acids 316 to 392 (77 residues), 42.6 bits, see alignment E=1.8e-14

Best Hits

Swiss-Prot: 90% identical to CLPX_ACIB3: ATP-dependent Clp protease ATP-binding subunit ClpX (clpX) from Acinetobacter baumannii (strain AB307-0294)

KEGG orthology group: K03544, ATP-dependent Clp protease ATP-binding subunit ClpX (inferred from 90% identity to abc:ACICU_00488)

Predicted SEED Role

"ATP-dependent Clp protease ATP-binding subunit ClpX" in subsystem Proteasome bacterial or Proteolysis in bacteria, ATP-dependent

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (438 amino acids)

>MPMX26_00409 ATP-dependent Clp protease ATP-binding subunit ClpX (Acinetobacter radioresistens SK82)
MSEHPQGQKHCSFCGKTQSEVGKLIAGEDAYICNECVDVCLDLVQTSQQVETGDWASRPL
PKPHEIRAALDQYVIGQDIAKKTLSVAVYNHYKRLKVSQNGQKTEDKVEIAKSNILLIGP
TGSGKTLLAQTLARLLDVPFAMADATTLTEAGYVGEDVENIVQKLLQKADYDIEKAQKGI
IYIDEIDKITRKSENPSITRDVSGEGVQQALLKMIEGTVASIPPQGGRKHPQQEFIQVDT
SNVLFICGGAFSGLEKIVQHRQEKGGIGFTAEVKSKDETKKLAELFRQVEPADLVKFGLI
PEFIGRLPVIATLEELDEDALMQILTEPKNALTRQYQYLFNMEDVDLVFEDSALRAVAKK
ALERNTGARGLRSILENVLLETMYDLPSRNDVGTVVINEAVINDGAEPEYRSERLPRQEG
EEGAVPKSELKVVNTKSA