Protein Info for MPMX19_06977 in Azospirillum sp. SherDot2

Annotation: 2-oxoglutarate dehydrogenase E1 component

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 899 PF16078: 2-oxogl_dehyd_N" amino acids 5 to 42 (38 residues), 40.7 bits, see alignment (E = 2.7e-14) TIGR00239: oxoglutarate dehydrogenase (succinyl-transferring), E1 component" amino acids 105 to 882 (778 residues), 803.1 bits, see alignment E=1.6e-245 PF00676: E1_dh" amino acids 165 to 473 (309 residues), 129.9 bits, see alignment E=2e-41 PF02779: Transket_pyr" amino acids 543 to 736 (194 residues), 152.2 bits, see alignment E=2.3e-48 PF16870: OxoGdeHyase_C" amino acids 742 to 883 (142 residues), 108.3 bits, see alignment E=6.3e-35

Best Hits

Predicted SEED Role

"2-oxoglutarate dehydrogenase E1 component (EC 1.2.4.2)" in subsystem TCA Cycle (EC 1.2.4.2)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.2.4.2

Use Curated BLAST to search for 1.2.4.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (899 amino acids)

>MPMX19_06977 2-oxoglutarate dehydrogenase E1 component (Azospirillum sp. SherDot2)
MSRPSSPLNAAGAAYLEALQERFRDDPASVDVSWRAVFQILDELGAVAPDKMTSGASASG
GPASGPLSLKHEDIRQRGHAAAALDPLGRASPPPGPASGDAETMRLRRLYQGTLTLETAH
IDDPALRSWLRDAYEGAADVPPADVRRRALSLLSAAEEFERLLGTRYPTKKRFGAEGMET
LIPLLDRILAAAAAAGVTEVQVGTMHRGRLSLMANVLGKPLVELFAGIKGMHPFQADPPV
PADVPYHMGVESSLSFGDGTLALTLSPNPSHLEAINPVTLGRARARQDLLREQGGEARRV
LCVLLHTDASVIGQGSVTEALQLSGVAGFTVAGTIHVIVNNQIGFTTESDEARTSLHCTG
LWKAVDSPILHVNADDPDAALRAADLAVAFRQTHGRDAVIDLVGYRRNGHNEIDEPRFTQ
PLDYAAIDAHPPVRALYAKRLAAEGAVGEGDVDALAAGHKARFQEALAAAADHRPNHDGF
PGGRWAPFASGGSAAGGSTAAEPDTGIGTDRLRALLAALAAIPDGLTVDRKVERVIRRRA
EEPLDWATGEALAFATLLADGVPVRLTGQDVVRGAFSHRHFALTDAVTGKRHVSLNHLGV
AQARFDVVNSPLSEYAVLGFEYGYSLERPDALVIWEAQFGDFANGAQILIDQFIVSAEDK
WRQPSGLVILLPHGLEGQGPEHSSARPERFLQMAARDNIRIAHPSTPANYFHLLRRQMLR
RDRKPLVVLSPKTLLRLPAAVSALADVAPGTGFQPVVVTAGERVGRILLCSGKLAYELER
ERAALHAGDVAVVRLEMLYPLPAAELSALFRRWPDASCLWVQEEPENLGAWSYLDRRLES
LRGAAGCAEPRVACVARAEAASPAGSFHGDHDADQRRLVGQAFAGLAAALPSRGKAAAE