Protein Info for MPMX19_06836 in Azospirillum sp. SherDot2

Annotation: Glutarate-semialdehyde dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00171: Aldedh
  • amino acids 33 to 492 (460 residues), 526.9 bits, E=2e-162

Best Hits

Swiss-Prot: 53% identical to DOEC_HALED: Aspartate-semialdehyde dehydrogenase (Non-phosphorylating) (doeC) from Halomonas elongata (strain ATCC 33173 / DSM 2581 / NBRC 15536 / NCIMB 2198 / 1H9)

KEGG orthology group: K00135, succinate-semialdehyde dehydrogenase (NADP+) [EC: 1.2.1.16] (inferred from 72% identity to mci:Mesci_2497)

MetaCyc: 53% identical to aspartate-semialdehyde dehydrogenase (non-phosphorylating) (Halomonas elongata DSM 2581)
1.2.1.M5 [EC: 1.2.1.M5]

Predicted SEED Role

No annotation

MetaCyc Pathways

• 4-aminobutanoate degradation III (2/2 steps found)
• ectoine degradation (2/4 steps found)
• L-canavanine degradation II (2/6 steps found)

KEGG Metabolic Maps

• Butanoate metabolism
• Glutamate metabolism
• Tyrosine metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.2.1.16

Use Curated BLAST to search for 1.2.1.16 or 1.2.1.M5

Protein Sequence (497 amino acids)

>MPMX19_06836 Glutarate-semialdehyde dehydrogenase (Azospirillum sp. SherDot2)
MTAQLSRLDRHDAVGRLSDRRLLRELAYVGGRWTAAPNGATFAVTDPASGRTLAQVAALD
AAQATAAVTAASAAFPAWSARLPQDRAARLRDWFDRIAAAREDLALLMTLEQGKPLAESR
GEIDYAASFVEWYAEEAKRVGVESIASHLPGAEMLLRREALGVVGMATPWNFPSAMLTRK
AAAALAAGCTVVAHASSETPLSALALAELAERAGIPAGVFNVLTGDPEPLVGALCDDARV
RAMSFTGSTEIGSRIAARCAPTMKRLVMELGGHAPLLVFADADLQRAVDIAIDAKFATSG
QDCLAANRIYVQRPLYDSFCAAFTARSAALRVGPGLEPEVQIGPLMNGRAVDKCARHVRD
ALDRGARCLTGGEIHPAGPLFYRPTVLADVAPDSLILREETFGPVAAILPFDDEAEAVAR
ANDTDYGLVAYLVTRDAGRILRLSRALHYGMVAVNRVKITGAPVPFGGVKQSGLGREGSR
HGLEAFTELKYVCLDAA