Protein Info for MPMX19_06792 in Azospirillum sp. SherDot2

Annotation: 2-hydroxymuconic semialdehyde dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR02299: 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase
  • amino acids 25 to 507 (483 residues), 801.6 bits, E=1.1e-245
• PF00171: Aldedh
  • amino acids 35 to 493 (459 residues), 573.8 bits, E=1.2e-176

Best Hits

Swiss-Prot: 42% identical to AMNC_PSESP: 2-aminomuconic 6-semialdehyde dehydrogenase (amnC) from Pseudomonas sp.

KEGG orthology group: K00151, 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase [EC: 1.2.1.60] (inferred from 71% identity to dge:Dgeo_2416)

MetaCyc: 42% identical to 2-aminomuconic 6-semialdehyde dehydrogenase monomer (Pseudomonas sp. AP3)
Aminomuconate-semialdehyde dehydrogenase. [EC: 1.2.1.32]

Predicted SEED Role

"5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase (EC 1.2.1.60)" in subsystem 4-Hydroxyphenylacetic acid catabolic pathway or Aromatic amino acid degradation or Central meta-cleavage pathway of aromatic compound degradation (EC 1.2.1.60)

MetaCyc Pathways

• 4-hydroxyphenylacetate degradation (6/8 steps found)
• 2-amino-3-carboxymuconate semialdehyde degradation to 2-hydroxypentadienoate (1/4 steps found)
• 2-aminophenol degradation (1/4 steps found)
• 2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA (1/5 steps found)
• L-tryptophan degradation IX (5/12 steps found)
• L-tryptophan degradation XII (Geobacillus) (5/12 steps found)
• 2-nitrobenzoate degradation I (1/7 steps found)
• L-tryptophan degradation III (eukaryotic) (6/15 steps found)
• 4-chloronitrobenzene degradation (1/9 steps found)
• L-tryptophan degradation XI (mammalian, via kynurenine) (7/23 steps found)

KEGG Metabolic Maps

• Benzoate degradation via hydroxylation
• Toluene and xylene degradation
• Tryptophan metabolism
• Tyrosine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.2.1.32 or 1.2.1.60

Protein Sequence (507 amino acids)

>MPMX19_06792 2-hydroxymuconic semialdehyde dehydrogenase (Azospirillum sp. SherDot2)
MASAFETNLATAERLLTRFRDRPLGHFIDGREVPGQSERLFDNLSPIDGGIINRVHAGNA
ADVDAAATAAQRAFPAWAALPGTERKRILHRVADGILARAEEIAVLESLDSGQPIRFMSK
AAERAAENFRFFADRAPDAANGLSLPARDHLNFTVRQALGPVAVITPWNTPFMLSTWKIA
PALAAGCTVVHKPAEWSPLTAMLLAEIMADAGVPAGVANLVNGLGEEAGKLLTEHPAIKA
VAFVGESTTGSHIMAQGAPTLKRVHFELGGKNPVVVFDDADLDRALDAVVFMIYSLNGQR
CTSSSRLLVQSGIHDAFVERLAERVARIRVGHPLDPATEVGPLVHERHLNKVLGYCAIAR
EDGATVKVGGVRAGEPGSGGNYVRPTLFTGAHNRMRIAQEEIFGPVLTAIPFQDEAEAVA
VANDVAYGLAGYVWTRDVSRANRVALKLDAGMVWINSENNRHLPTPFGGMKASGIGRDGG
DYSFDFYMETKNICVALDTHTVPKLGA