Protein Info for MPMX19_05833 in Azospirillum sp. SherDot2

Annotation: Cyclohexadienyl dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF03807: F420_oxidored
  • amino acids 18 to 109 (92 residues), 39 bits, E=2e-13
• PF03446: NAD_binding_2
  • amino acids 18 to 142 (125 residues), 37.6 bits, E=4.5e-13
• PF02153: PDH_N
  • amino acids 31 to 184 (154 residues), 132.1 bits, E=2.6e-42
• PF20463: PDH_C
  • amino acids 189 to 288 (100 residues), 103.6 bits, E=1.3e-33

Best Hits

Swiss-Prot: 40% identical to TYRC_ZYMMO: Cyclohexadienyl dehydrogenase (tyrC) from Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)

KEGG orthology group: K00220, cyclohexadieny/prephenate dehydrogenase [EC: 1.3.1.12 1.3.1.43] (inferred from 89% identity to azl:AZL_d00870)

Predicted SEED Role

"Cyclohexadienyl dehydrogenase (EC 1.3.1.12)(EC 1.3.1.43)" in subsystem Chorismate Synthesis or Phenylalanine and Tyrosine Branches from Chorismate (EC 1.3.1.12, EC 1.3.1.43)

MetaCyc Pathways

• superpathway of aromatic amino acid biosynthesis (18/18 steps found)
• superpathway of L-tyrosine biosynthesis (10/10 steps found)
• L-tyrosine biosynthesis I (3/3 steps found)
• 4-hydroxy-3-prenylbenzoate biosynthesis (3/4 steps found)
• L-tyrosine biosynthesis III (3/4 steps found)
• superpathway of chorismate metabolism (38/59 steps found)
• superpathway of novobiocin biosynthesis (6/19 steps found)

KEGG Metabolic Maps

• Novobiocin biosynthesis
• Phenylalanine, tyrosine and tryptophan biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.3.1.12 or 1.3.1.43

Protein Sequence (304 amino acids)

>MPMX19_05833 Cyclohexadienyl dehydrogenase (Azospirillum sp. SherDot2)
MSTATTASASAPGPLFDRVAIVGIGLIGSSLARALAEYGIARQVVCTDRSDAACAKALEL
GIVAEASTDPAAALAGADLVVLSTPVGSYAAVAEAIGPLLQRGTIVTDVGSVKQATLRDV
GPHLPDGVHLIPGHPVAGTEHSGPEAGFATLFQGRWCILTPPSGADRHALEQVTELWRRV
GSTVEIMEASHHDRVLAITSHLPHLIAYTIVGTASDLEEDTKSEVIKFSAGGFRDFTRIA
ASDPVMWRDVFLNNREAVLEILQRFTEDLTALQRAIRWGEGEQLQDHFTKTRAVRRGIID
AKQA