Protein Info for MPMX19_05745 in Azospirillum sp. SherDot2

Annotation: Sensor histidine kinase RcsC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1142 transmembrane" amino acids 12 to 33 (22 residues), see Phobius details amino acids 287 to 306 (20 residues), see Phobius details PF22588: dCache_1_like" amino acids 186 to 271 (86 residues), 33.6 bits, see alignment 1.6e-11 PF13426: PAS_9" amino acids 385 to 438 (54 residues), 14.3 bits, see alignment 1.9e-05 amino acids 463 to 566 (104 residues), 48.2 bits, see alignment E=5e-16 TIGR00229: PAS domain S-box protein" amino acids 448 to 573 (126 residues), 92 bits, see alignment E=1.6e-30 PF13188: PAS_8" amino acids 451 to 500 (50 residues), 29.8 bits, see alignment (E = 1.9e-10) PF00989: PAS" amino acids 452 to 564 (113 residues), 44.7 bits, see alignment E=5.6e-15 PF08448: PAS_4" amino acids 457 to 569 (113 residues), 36 bits, see alignment E=3.2e-12 PF00512: HisKA" amino acids 587 to 652 (66 residues), 74.1 bits, see alignment 3.4e-24 PF02518: HATPase_c" amino acids 700 to 820 (121 residues), 94.3 bits, see alignment E=2.9e-30 PF00072: Response_reg" amino acids 860 to 971 (112 residues), 85.2 bits, see alignment E=1.6e-27 PF01627: Hpt" amino acids 1043 to 1118 (76 residues), 35.1 bits, see alignment 5.8e-12

Best Hits

KEGG orthology group: None (inferred from 83% identity to azl:AZL_d01830)

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1142 amino acids)

>MPMX19_05745 Sensor histidine kinase RcsC (Azospirillum sp. SherDot2)
MRGRLHLQGFIAAIWTATLVIAAGLWAAALTLAHYDDAEAMARAERDSGNLARVVAEQAT
RTIAEADQILLFLIDDYHEHGDNWTHGITQMLRQAVERSSILVQLAVIDEHGDLIHTSVE
DAPVRIHLADREHFRVHANNPAAGLFIGKPVFGRASGKWSIQLTRRISNSDGSFAGVLVA
SMDPFYFSRSLEELDVGPNGAVAIVGTDGILRARSLMNDRIVGRDVGESPTLQMARLRPS
GFVRTASVIDGIPRLQSFRTLASYPLIVTTAFDEGSFLADTRRRQRVYLLAAAACSAGLI
GLALLATRQTARLAALARQLAQSEERFRDQAETASDWFWEMDADLRFSNLAGPLVPHVVN
GTLPIGLRREDVALREPGDAPKWEQHRQAMERREPFRNFRYRVMTAAGLRYFSVSGRPIF
EESGEFRGYRGSATDITERELAANRLASSEARYRAMFEAVGQPIVTIDEHGTIDAFNRAA
ERLFGYRAADMVGGPMTRLMPTAMGAVHDGLLATYRESDASAPRSEIRELTGRRKDGSEF
PLEVTLAGWREGDRRYVTGALRDVTAQREIEASLRRAKEAADQANRAKGEFLATMSHEIR
TPMNGVLGALALVEGPNLNEEQRQLLDVANRSGNALLQIIDDILDLSKLEAGKAEVEPVD
FELRAVLGDSIDLLEPTACGRGLILTREVASAVPDRVRADLRRIRQVLVNLVGNALKFTN
RGGVSVRVALEGAGKGAAALAADGGFFLRFEVVDTGIGIPENVQQTLFRRFTQADSSTTR
RFGGTGLGLAISRELVTLMGGRIGVVSTEGKGSTFWFTVRCEPAADPSAGVLTVPCAPEP
VPAAGDGVAGGTAQPAGLHVLVAEDNEINRDIVVTMLRRAGHRVTAVEDGLQAVRLVDEG
GFDLVLMDVQMPVMDGVTATRHIRTMPGEAARLPIVALTGNVMPGHRAEYLAAGMTAYLT
KPIVSADLFDVLASVAASRAAGGTWGDSGLPPRAPLASASPATPSPAPSEAEAWRAVPLL
DDGQASSLRAVIGEEAWAQTVVAFRRTVSDSVAAIRAAAGREGRAVPPVRIAHTLKGTAA
NIGAVRLSRLASLLEQRALDHGGWTAGDPHCEALEGVAEATLDALASRFQPADDAAMEQE
TA