Protein Info for MPMX19_05290 in Azospirillum sp. SherDot2

Annotation: Hydrogenase transcriptional regulatory protein hupR1

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 495 PF00072: Response_reg" amino acids 9 to 116 (108 residues), 79.7 bits, see alignment E=4.8e-26 PF14532: Sigma54_activ_2" amino acids 170 to 337 (168 residues), 88.9 bits, see alignment E=9.5e-29 PF00158: Sigma54_activat" amino acids 171 to 332 (162 residues), 230.1 bits, see alignment E=3.3e-72 PF02954: HTH_8" amino acids 445 to 485 (41 residues), 47.5 bits, see alignment 2.9e-16

Best Hits

Swiss-Prot: 53% identical to HOXA_CUPNH: Hydrogenase transcriptional regulatory protein HoxA (hoxA) from Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337)

KEGG orthology group: None (inferred from 95% identity to azl:AZL_c01970)

Predicted SEED Role

"Hydrogenase transcriptional regulatory protein HoxA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (495 amino acids)

>MPMX19_05290 Hydrogenase transcriptional regulatory protein hupR1 (Azospirillum sp. SherDot2)
MTDPARPGILVVDDEPRSVEVIARLLDEEFEVFTALSAAEGLRLLETEWIQVVFSDQRMP
EVSGVEFLTQVRERWPDVVRIVITGYIDPEDIIGAINTAGIHQFITKPWHPDHLLLTARN
AAKLYRLQREHDRLTSELKLLPPLAETRVATRRERVRQSYRFDGLIRAEGSPVDEVCRQA
ERVSGFNVPVLVLGETGTGKELLARAIHYGSPRSDQPFYCENCGAIPDELLESELFGHKK
GAFTGAHSNRVGLLEQADGGTIFLDEIGDISPAFQVRLLRFLQEGEIRPVGSNETRRVDV
RVVAATHRDLTAEVKAGRFREDLYYRLSTMTLTMPPLRDRPDDIPVLARHILDRLSTAHG
KPVSGFAADTLACLESYGWPGNVRELQNEIMRMLVLCEGDTLDADLLSDQVLRGAALNAR
PASPEDGPLPPLDLIGQGGPLKSRIERVEAGILMETLVRCRWNKSKAADELGLSRMGLRA
KLERYGIERGPAQRH