Protein Info for MPMX19_05154 in Azospirillum sp. SherDot2

Annotation: Isoleucine 2-epimerase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00202: Aminotran_3
  • amino acids 28 to 432 (405 residues), 249.7 bits, E=2.3e-78

Best Hits

KEGG orthology group: K00823, 4-aminobutyrate aminotransferase [EC: 2.6.1.19] (inferred from 94% identity to azl:AZL_a10460)

Predicted SEED Role

"Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)" in subsystem Biotin biosynthesis (EC 2.6.1.62)

MetaCyc Pathways

• 4-aminobutanoate degradation II (2/2 steps found)
• 4-aminobutanoate degradation III (2/2 steps found)
• superpathway of 4-aminobutanoate degradation (2/3 steps found)
• 4-aminobutanoate degradation I (1/2 steps found)
• biotin biosynthesis I (9/15 steps found)
• GABA shunt I (1/4 steps found)
• GABA shunt II (1/4 steps found)
• biotin biosynthesis from 8-amino-7-oxononanoate I (1/4 steps found)
• 4-aminobutanoate degradation V (3/7 steps found)
• superpathway of L-arginine and L-ornithine degradation (7/13 steps found)
• superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation (5/11 steps found)
• nicotine degradation I (pyridine pathway) (7/17 steps found)

KEGG Metabolic Maps

• Alanine and aspartate metabolism
• Biotin metabolism
• Butanoate metabolism
• Glutamate metabolism
• Propanoate metabolism
• beta-Alanine metabolism

Isozymes

Compare fitness of predicted isozymes for: 2.6.1.19, 2.6.1.62

Use Curated BLAST to search for 2.6.1.19 or 2.6.1.62

Protein Sequence (435 amino acids)

>MPMX19_05154 Isoleucine 2-epimerase (Azospirillum sp. SherDot2)
MADALGPKSRALVDRDAGAFLRQSLSTPCLSAIRRAEGIWIEDMDGRRFMDFHGNSVHHI
GYAHPRLLAALKAQMDDLSFAPRRFACEPAAELAERLAAIAPTGPGSRVLFAPGGSEGIE
IALKLARVATGRFKTVSFWDAFHGAGFGASGVGGEALFRSHGIGPLLPGTEHVAPFACAR
CPYGFDPAPGGGPDLDACRMTCARMLRYVLEKEGDVAAVVAEPVRAVPYVPPPGFWAEVR
RACDAAGALLIFDEIPTGLGKTGSLFSHEPFGATPDILVLGKALGGAMLPLAAVIARPGL
DVAADRALGHYTHEKNPLLARAGLTTLDIVRDEGLAERAATLGAHALDRLRELTAALPGI
AGIRGAGLLIGVELADHDGRSGADRAEAAFYAALAAGVSLKISQGTVLTLSPPMIIEQAD
LDRALAIVARAIASA