Protein Info for MPMX19_04899 in Azospirillum sp. SherDot2

Annotation: 3-methylmercaptopropionyl-CoA dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 596 PF12418: AcylCoA_DH_N" amino acids 4 to 34 (31 residues), 43.7 bits, see alignment (E = 8e-15) PF02771: Acyl-CoA_dh_N" amino acids 79 to 156 (78 residues), 44.5 bits, see alignment E=6.7e-15 PF02770: Acyl-CoA_dh_M" amino acids 162 to 271 (110 residues), 51.7 bits, see alignment E=2.9e-17 PF00441: Acyl-CoA_dh_1" amino acids 282 to 450 (169 residues), 76.2 bits, see alignment E=1.1e-24 PF08028: Acyl-CoA_dh_2" amino acids 298 to 443 (146 residues), 28.1 bits, see alignment E=8e-10 PF22924: ACOX_C_alpha1" amino acids 311 to 445 (135 residues), 30.6 bits, see alignment E=9.8e-11 PF12806: Acyl-CoA_dh_C" amino acids 473 to 591 (119 residues), 123.1 bits, see alignment E=2.7e-39

Best Hits

KEGG orthology group: None (inferred from 97% identity to azl:AZL_c00490)

Predicted SEED Role

"Acyl-CoA dehydrogenase (EC 1.3.8.7)" (EC 1.3.8.7)

MetaCyc Pathways

Isozymes

Compare fitness of predicted isozymes for: 1.3.8.7

Use Curated BLAST to search for 1.3.8.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (596 amino acids)

>MPMX19_04899 3-methylmercaptopropionyl-CoA dehydrogenase (Azospirillum sp. SherDot2)
MPIYKAPLEDVRFVLDEIVGLDKLSALPGYEDATPELVGQVLEEGARLCEEVLFPLNQSG
DGEGCHFENGEVRTPKGFKEAYTTYIEAGWQGLACDPAYGGQGLPKLVNTMLEEFICSAN
LSFGMYPGLSLGAYNALAMYGSDELKQRFLPKLVDGTWSGTMCLTEPHCGTDLGIIRTKA
VPDGEGGYKITGTKIFISAGEHDLTENILHLVLARLPDAPAGTRGISLFLVPKFMPNADG
TSGARNGVACGSIEHKMGIKASSTCVMNFEDATGWLVGEPHKGMRAMFVMMNAARLAVGI
QGLGLAEVSYQNAVNYARERLQGRSLSGVKAPDKPADPIIVHPDVRRNLLTARAFTEGAR
ALGALTAYKLDVAEKHPDERTRRDADEFVQLMTPVVKALFTDIGFDSANIAVQVHGGHGF
IWETGVEQYVRDARICQIYEGTNGIQALDLVGRKLPQDIGRLLRHFFHPVGRDIEAAMEK
DELGEFVMPLAKAFAKLQQATALIAQKGLKDPEEAGAAASDYLRLFGLVALGWSWLTMVE
KAQARLEAGEGNAAFFDAKIKTARFYMTKLLPQTNSLFITIAAGAKPLMELEDAAF