Protein Info for MPMX19_04815 in Azospirillum sp. SherDot2

Annotation: Adenylosuccinate synthetase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00709: Adenylsucc_synt
  • amino acids 5 to 422 (418 residues), 595.5 bits, E=2.5e-183
• TIGR00184: adenylosuccinate synthase
  • amino acids 6 to 428 (423 residues), 532.6 bits, E=3.4e-164

Best Hits

Swiss-Prot: 77% identical to PURA_RHOCS: Adenylosuccinate synthetase (purA) from Rhodospirillum centenum (strain ATCC 51521 / SW)

KEGG orthology group: K01939, adenylosuccinate synthase [EC: 6.3.4.4] (inferred from 98% identity to azl:AZL_c04110)

Predicted SEED Role

"Adenylosuccinate synthetase (EC 6.3.4.4)" in subsystem CBSS-262719.3.peg.410 or Purine conversions (EC 6.3.4.4)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (44/46 steps found)
• superpathway of purine nucleotides de novo biosynthesis I (21/21 steps found)
• superpathway of purine nucleotides de novo biosynthesis II (24/26 steps found)
• superpathway of purine nucleotide salvage (13/14 steps found)
• superpathway of adenosine nucleotides de novo biosynthesis I (5/5 steps found)
• superpathway of adenosine nucleotides de novo biosynthesis II (6/7 steps found)
• adenosine ribonucleotides de novo biosynthesis (3/3 steps found)

KEGG Metabolic Maps

• Alanine and aspartate metabolism
• Biosynthesis of alkaloids derived from histidine and purine
• Purine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.3.4.4

Protein Sequence (430 amino acids)

>MPMX19_04815 Adenylosuccinate synthetase (Azospirillum sp. SherDot2)
MANVAVVGAQWGDEGKGKIVDWLSSRADVVVRFQGGHNAGHTLVINGVEYKLSLLPSGVV
RQSKLSVIGNGVVFDPWAFIREVNAIKEKGVTVNPENLIVAENVPLILPVHSALDKAREE
AKGAGKIGTTGRGIGPAYEDKVARRAIRLCDLTDDAVLVEKVDALLAHHNALFRALGAPE
MTPADILEPLREIAPQVLPYAAVVWKQLDELRRAGKRILFEGAQGTMLDIDHGTYPYVTS
SNTVAGNAAAGSGMGPRAVGYVLGICKAYTTRVGSGPFPTELLDDIGELIGQKGKEFGVV
TGRKRRCGWFDAVMVRQAIKTGGIDGIALTKLDVLDGFDEIKVCVGYKLDGQELDYYPSN
AGSQARVEPIYETFEGWKDTTRGARSWAELPAQAVKYVRHIEELIQAPVALLSTSPERDD
TILMTDPFAD