Protein Info for MPMX19_04552 in Azospirillum sp. SherDot2

Annotation: D-hydantoinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR02033: dihydropyrimidinase
  • amino acids 7 to 461 (455 residues), 551.7 bits, E=7e-170
• PF01979: Amidohydro_1
  • amino acids 51 to 443 (393 residues), 83.6 bits, E=1.6e-27
• PF07969: Amidohydro_3
  • amino acids 363 to 443 (81 residues), 35.5 bits, E=8.5e-13

Best Hits

KEGG orthology group: K01464, dihydropyrimidinase [EC: 3.5.2.2] (inferred from 96% identity to azl:AZL_a04910)

Predicted SEED Role

"D-hydantoinase (EC 3.5.2.2)" in subsystem Hydantoin metabolism (EC 3.5.2.2)

MetaCyc Pathways

• superpathway of pyrimidine ribonucleosides degradation (5/5 steps found)
• thymine degradation (3/3 steps found)
• uracil degradation I (reductive) (3/3 steps found)

KEGG Metabolic Maps

• Drug metabolism - other enzymes
• Pantothenate and CoA biosynthesis
• Pyrimidine metabolism
• beta-Alanine metabolism

Isozymes

Compare fitness of predicted isozymes for: 3.5.2.2

Use Curated BLAST to search for 3.5.2.2

Protein Sequence (474 amino acids)

>MPMX19_04552 D-hydantoinase (Azospirillum sp. SherDot2)
MPQFDTVIRNGTLATASDVFAADLGVIGGRIAAIGAGLGPGAREIDATGRLVMPGGVDGH
CHLDQPTSDGSQSADDFETGTRSAAYGGTTTVIPFACQFKGQSLRDAVTDYHRRADGKAV
IDYAFHLIVSDPTDQLLGQDLPALIHDGYTSFKIYMTYDDMKLNDRQVLELLSVARRDGA
MAMIHAENADFIGWLTDKLLAAGHTAPRYHADSRPMLVEREATHRAIAMAELADVPILIV
HVSGREAIEQIHWAQGRGMRIYAETCPQYMVLTEHDLHGHGMEGAKCICSPPPRDKANQA
AVWDALAGGTFHIVSSDHAPFRYQDPKGKMLHGADTPFNWIPNGVPGIETRLPILFSEGV
KKGRISLQRFVELSSTNPAKMYGLHPRKGSLAIGADADIVIYDPDRKVTITNAMLHHNVD
YTPYEGLEVTGWPETVLSRGEVVVEGGACVAQPGRGAFLRCDTPDLARPKVGAA