Protein Info for MPMX19_04437 in Azospirillum sp. SherDot2

Annotation: Oxalyl-CoA decarboxylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 587 TIGR03254: oxalyl-CoA decarboxylase" amino acids 25 to 578 (554 residues), 1002.4 bits, see alignment E=3e-306 PF02776: TPP_enzyme_N" amino acids 28 to 144 (117 residues), 103.2 bits, see alignment E=1.2e-33 PF00205: TPP_enzyme_M" amino acids 219 to 348 (130 residues), 117.6 bits, see alignment E=5.3e-38 PF02775: TPP_enzyme_C" amino acids 417 to 559 (143 residues), 88.4 bits, see alignment E=6.6e-29

Best Hits

Swiss-Prot: 60% identical to OXC_OXAFO: Oxalyl-CoA decarboxylase (oxc) from Oxalobacter formigenes

KEGG orthology group: K01577, oxalyl-CoA decarboxylase [EC: 4.1.1.8] (inferred from 98% identity to azl:AZL_a03520)

MetaCyc: 60% identical to oxalyl-CoA decarboxylase monomer (Oxalobacter formigenes)
Oxalyl-CoA decarboxylase. [EC: 4.1.1.8]

Predicted SEED Role

"Oxalyl-CoA decarboxylase (EC 4.1.1.8)" in subsystem Alkaloid biosynthesis from L-lysine (EC 4.1.1.8)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.1.1.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (587 amino acids)

>MPMX19_04437 Oxalyl-CoA decarboxylase (Azospirillum sp. SherDot2)
MSTAAATITKNQATEASVVEDAPALTDGFQLVIDALKLNDINNLYVVPGIPISDLLRMAQ
AEGMRVVSFRHEQNAGNAAAIAGFMTKKPGVCMTVSAPGFLNGLTALANATTNCFPMILI
SGSSEREVVDLQQGDYEEMDQLAIAKPLCKAAFRILHAQDIGIGVARAIRAAVSGRPGGV
YLDLPAKLFSQVMDAAEGAKSLVKVVDPTPAQYPSAEAVNRALDLLKGAKRPLVIFGKGA
AYAQADETIRSFVEKSGIPFLQMSMAKGLLPDTHPQSAGAARSLVLQEADVVMLVGARLN
WLLSHGKGKTWGKPGSKKFIQVDIEPREMDSNVEIHAPLVGDIASVMEVMLKGIDGGLTP
PTDWMATVAAKREQNVAKMAPKLMSNASPMNFHGALGALRRIIKERPDALLVNEGANTLD
LARGIIDMYEPRKRLDVGTWGVMGVGMGYAVAAAVESGKPVLAVEGDSAFGFSGMEVETI
CRYNLPVCIVIFNNNGIYRGTDVNPTGGNDPSPMVFVPGSRYDKMMEAFGGVGVHVTNPD
ELYRAVNEAMDSGRPTLINAVIDPAAGTESGNIGSLNPTSSVRKMPS