Protein Info for MPMX19_04036 in Azospirillum sp. SherDot2

Annotation: Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 336 PF01408: GFO_IDH_MocA" amino acids 3 to 125 (123 residues), 90.6 bits, see alignment E=1.9e-29 PF22725: GFO_IDH_MocA_C3" amino acids 136 to 247 (112 residues), 55.1 bits, see alignment E=1.2e-18 PF02894: GFO_IDH_MocA_C" amino acids 144 to 319 (176 residues), 70.9 bits, see alignment E=2.1e-23

Best Hits

Swiss-Prot: 83% identical to IOLG_AGRFC: Inositol 2-dehydrogenase (iolG) from Agrobacterium fabrum (strain C58 / ATCC 33970)

KEGG orthology group: K00010, myo-inositol 2-dehydrogenase [EC: 1.1.1.18] (inferred from 87% identity to mno:Mnod_7807)

MetaCyc: 58% identical to myo-inositol 2-dehydrogenase (Klebsiella aerogenes)
Inositol 2-dehydrogenase. [EC: 1.1.1.18]

Predicted SEED Role

"Myo-inositol 2-dehydrogenase 1 (EC 1.1.1.18)" in subsystem Inositol catabolism (EC 1.1.1.18)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.1.1.18

Use Curated BLAST to search for 1.1.1.18

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (336 amino acids)

>MPMX19_04036 Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase (Azospirillum sp. SherDot2)
MTVRIGIIGTGAIGRDHARRINQVLAGGKIVALTDVNRGSAEAVRAEIAPDAEIFQTGEE
LIASPLVDAVLVTSWGASHEQYVLAAIAAGKPCFCEKPLATTADGAKRIVDAEVAHGKRL
VQVGFMRRYDAGYIALKEAVTSRTGAPIMVHAAHRNPTVPQHYVTPMAIHDTLIHEIDVF
RWLLDDDYVSARVIFPRRAARSHGKLRDPQVVLLETAKGVVIDVEIFVNCHYGYDIQCEV
VGEDGIARLPEPMAVQMRLNASLQNPILTDWKDRFIASYDVELQDFLKAAAQGTATGPTC
WDGYVAAITSDACVTAQEREGEAVAITLPSRPALYS