Protein Info for MPMX19_03939 in Azospirillum sp. SherDot2

Annotation: Enoyl-CoA-hydratase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00378: ECH_1
  • amino acids 11 to 259 (249 residues), 179.5 bits, E=7.6e-57
• PF16113: ECH_2
  • amino acids 14 to 184 (171 residues), 94.7 bits, E=8e-31

Best Hits

KEGG orthology group: K13766, methylglutaconyl-CoA hydratase [EC: 4.2.1.18] (inferred from 95% identity to azl:AZL_a02270)

MetaCyc: 49% identical to 3-methylglutaconyl-CoA hydratase (Pseudomonas putida)
Methylglutaconyl-CoA hydratase. [EC: 4.2.1.18]

Predicted SEED Role

"Methylglutaconyl-CoA hydratase (EC 4.2.1.18)" in subsystem Benzoate transport and degradation cluster or HMG CoA Synthesis or Leucine Degradation and HMG-CoA Metabolism (EC 4.2.1.18)

MetaCyc Pathways

• L-leucine degradation I (5/6 steps found)
• ferrichrome A biosynthesis (2/5 steps found)

KEGG Metabolic Maps

• Valine, leucine and isoleucine degradation

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.2.1.18

Protein Sequence (260 amino acids)

>MPMX19_03939 Enoyl-CoA-hydratase (Azospirillum sp. SherDot2)
MSDILIEVADTGVATVTMNRGDVHNAFNEQVIADLTSAFRRVGEDPAVRVVLLRGVGKSF
SAGADLSWMKKMAGYSREENLADAMGLATMLRTLDECPKPTVAVVQGPAFGGGVGLVSAC
DIAIGVETATFALSEVRLGIIPAAISPYVIAAIGERACRRYFLTGERFSAAEAHRIGLLH
ELTNAGGLEEAVAKTVKNLMDSAPTAVTAAKELIRAVARRPLTDDVVRDTAERIARQRAS
AEGKEGVGAFLDKRTPSWRS