Protein Info for MPMX19_03307 in Azospirillum sp. SherDot2

Annotation: Galactarate dehydratase (L-threo-forming)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF08666: SAF
  • amino acids 17 to 85 (69 residues), 38.6 bits, E=1.9e-13
• PF04295: GD_AH_second
  • amino acids 113 to 255 (143 residues), 147 bits, E=5.7e-47
• PF20629: GD_AH_C
  • amino acids 264 to 506 (243 residues), 341.2 bits, E=4.5e-106

Best Hits

KEGG orthology group: K01685, altronate hydrolase [EC: 4.2.1.7] (inferred from 96% identity to azl:AZL_a06380)

Predicted SEED Role

"Altronate dehydratase (EC 4.2.1.7)" (EC 4.2.1.7)

MetaCyc Pathways

• superpathway of hexuronide and hexuronate degradation (9/10 steps found)
• D-galacturonate degradation I (5/5 steps found)
• superpathway of microbial D-galacturonate and D-glucuronate degradation (19/31 steps found)

KEGG Metabolic Maps

• Pentose and glucuronate interconversions

Isozymes

Compare fitness of predicted isozymes for: 4.2.1.7

Use Curated BLAST to search for 4.2.1.7

Protein Sequence (508 amino acids)

>MPMX19_03307 Galactarate dehydratase (L-threo-forming) (Azospirillum sp. SherDot2)
MPSSVPELLLLNPSDSVAVATREIPAGSAVSVGSFAGTAAATIPSGHKIAIRAVAPGEPV
VKYGQVIGTATQPIEPGQHVHVHNLGMGEARLDHGSTRIVEAERGAEEATFLGIRRPSGQ
IATRNYIGVIASVNCSATVCKRIADAFNGNALADYPNVDGVVAIVHGSGCGMNGTGEGMA
ILRRTLRGYADHANFAGLLLIGLGCEMNQIAPLAQTLAPRPDGLIATLTIQEEGGTRETI
ERGVALVRAMLPIANDVRREPVPASHLTVGLQCGGSDGYSGITANPVLGAAVDLLVAHGG
TAILSETPEIYGAEHLLTARAASPAVADRLMDRIRWWEDYTRLHKGDMNNNPSPGNKAGG
ITTILEKSLGAVAKGGGTRLNAVVDYAEPVTDHGLVFMDTPGYDPVSATGQVAGGANLIA
FTTGRGSTYGCKPTPSLKIATNSALYARMGDDMDFNGGAVLDGGTSVAEAGAALFRLMLD
TASGHRTRSEENGIGDNEFVPWQIGAVM