Protein Info for MPMX19_02921 in Azospirillum sp. SherDot2

Annotation: Formyltransferase/hydrolase complex Fhc subunit A

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR03121: formylmethanofuran dehydrogenase subunit A
  • amino acids 3 to 543 (541 residues), 686 bits, E=1.6e-210
• PF07969: Amidohydro_3
  • amino acids 44 to 497 (454 residues), 156.5 bits, E=8.7e-50

Best Hits

KEGG orthology group: K00200, formylmethanofuran dehydrogenase subunit A [EC: 1.2.99.5] (inferred from 63% identity to sno:Snov_0756)

Predicted SEED Role

"Formylmethanofuran dehydrogenase subunit A (EC 1.2.99.5)" in subsystem Methanogenesis (EC 1.2.99.5)

MetaCyc Pathways

• methyl-coenzyme M oxidation to CO₂ II (4/6 steps found)
• methanogenesis from H₂ and CO₂ (3/6 steps found)
• methyl-coenzyme M oxidation to CO₂ I (3/6 steps found)
• reductive acetyl coenzyme A pathway II (autotrophic methanogens) (3/6 steps found)
• gluconeogenesis II (Methanobacterium thermoautotrophicum) (11/18 steps found)
• methoxylated aromatic compound degradation II (4/9 steps found)
• superpathway of methanogenesis (5/21 steps found)
• Methanobacterium thermoautotrophicum biosynthetic metabolism (21/56 steps found)

KEGG Metabolic Maps

• Folate biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 1.2.99.5

Use Curated BLAST to search for 1.2.99.5

Protein Sequence (558 amino acids)

>MPMX19_02921 Formyltransferase/hydrolase complex Fhc subunit A (Azospirillum sp. SherDot2)
MLTKLTGGRLFDPANGRHGEVADLWLRDDRIAADPGPGATPDAVHDVTGKVVMAGAIDIH
SHIAGGKVNLARLLMGEEHDRHRFAGHACGHNRIGGGSGIATPSTHTTGARYIEMGFTAA
FEPAMLGSNARHAHLEMSDIPYIDTGGYLVLGNDDFLLDLIATNAGQAAVNDYVAWMLTA
TQSLAVKVVNPGGINAFKFNARSLDLDEAGPHYGVTPRSVLTVLARAVYELGLPHPLHVH
GCNLGVPGNVATTLDTIQAASGLPMHMTHIQFHSYDTAGDRKFSSGAAALAEAVNRTPTL
SVDIGQVMFGQTVTASADTMAQRHTAPLAHPRKWLAMDIECDAGCGVVPFRYRDTSYVNA
LQWAIGLELFLLLDDPWRVFLTTDHPNGAPFTFYPELIRLLMDRDYRLAKLAEIHPDAPA
HTTLGSITREYTLAEIAIMTRAAPARILGLADRGHLAPGASADVTVYSDLPDRRAMFERP
DLVFKSGRLVVRDGVLVAMAQGCTHVVRPGFDDLIERRIARHFDERIGLPIKHFRIQDAE
IRHGAGPQLHPCRRREVP