Protein Info for MPMX19_02315 in Azospirillum sp. SherDot2

Annotation: Na(+)/H(+) antiporter NhaA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 signal peptide" amino acids 1 to 18 (18 residues), see Phobius details amino acids 30 to 33 (4 residues), see Phobius details transmembrane" amino acids 19 to 29 (11 residues), see Phobius details amino acids 60 to 78 (19 residues), see Phobius details amino acids 99 to 118 (20 residues), see Phobius details amino acids 125 to 145 (21 residues), see Phobius details amino acids 155 to 175 (21 residues), see Phobius details amino acids 181 to 198 (18 residues), see Phobius details amino acids 210 to 240 (31 residues), see Phobius details amino acids 262 to 283 (22 residues), see Phobius details amino acids 295 to 319 (25 residues), see Phobius details amino acids 334 to 358 (25 residues), see Phobius details amino acids 364 to 385 (22 residues), see Phobius details PF06965: Na_H_antiport_1" amino acids 8 to 385 (378 residues), 499.9 bits, see alignment E=2.1e-154 TIGR00773: Na+/H+ antiporter NhaA" amino acids 9 to 385 (377 residues), 463 bits, see alignment E=3.6e-143

Best Hits

Swiss-Prot: 60% identical to NHAA_RHORT: Na(+)/H(+) antiporter NhaA (nhaA) from Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIB 8255 / S1)

KEGG orthology group: K03313, Na+:H+ antiporter, NhaA family (inferred from 91% identity to azl:AZL_002470)

Predicted SEED Role

"Na+/H+ antiporter NhaA type" in subsystem Na(+) H(+) antiporter

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (400 amino acids)

>MPMX19_02315 Na(+)/H(+) antiporter NhaA (Azospirillum sp. SherDot2)
MTLRRLATFLKTESASGVVLMIAALLALIWANSPAAPLYDAILAMKVAVTAGGVGLDKPL
ILWINDGLMAIFFLLVGLEIKREVLEGELSSPAKAMLPGIAALGGMAVPALVYCLFAQAE
PGALQGWAIPAATDIAFALGVLALLGNRVPSSLRVFLLALAIMDDLGAIMIIAIFYSHGL
VPLALGLAAASAVGLWLLNRAGVRSLTPYLVLGLILWVCVLKSGIHATLAGVVLAFAIPL
RVNDRAGKRAPDAPLYRLEHALHPWVAFLIMPVFALANAGVPLDGITPASLLEPVPLGIA
LGLFLGKQAGVFLAVWVAVRTGVVERPARASWGQIYGVAVLTGIGFTMSLFIGTLAFADP
HHAVAVRLGVLTGSLASALAGYALLHAAGSARAREVARAS