Protein Info for MPMX19_02253 in Azospirillum sp. SherDot2

Annotation: Adaptive-response sensory-kinase SasA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 661 signal peptide" amino acids 1 to 22 (22 residues), see Phobius details transmembrane" amino acids 198 to 220 (23 residues), see Phobius details amino acids 229 to 251 (23 residues), see Phobius details amino acids 257 to 282 (26 residues), see Phobius details amino acids 294 to 314 (21 residues), see Phobius details amino acids 321 to 341 (21 residues), see Phobius details amino acids 351 to 372 (22 residues), see Phobius details amino acids 385 to 404 (20 residues), see Phobius details PF07696: 7TMR-DISMED2" amino acids 42 to 185 (144 residues), 86.3 bits, see alignment E=3.9e-28 PF07695: 7TMR-DISM_7TM" amino acids 198 to 401 (204 residues), 64.8 bits, see alignment E=2.2e-21 PF00512: HisKA" amino acids 427 to 487 (61 residues), 38.2 bits, see alignment 2.5e-13 PF02518: HATPase_c" amino acids 538 to 646 (109 residues), 84 bits, see alignment E=2e-27

Best Hits

KEGG orthology group: None (inferred from 79% identity to azl:AZL_002720)

Predicted SEED Role

"Osmosensitive K+ channel histidine kinase KdpD (EC 2.7.3.-)" in subsystem Potassium homeostasis (EC 2.7.3.-)

Isozymes

Compare fitness of predicted isozymes for: 2.7.3.-

Use Curated BLAST to search for 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (661 amino acids)

>MPMX19_02253 Adaptive-response sensory-kinase SasA (Azospirillum sp. SherDot2)
MAGPIGLLTALLLWFAGTAAATVSGVEPLRLAPATASATLAGHFARLVDPDRKLDFAAIL
KADADGQMEPREDFRGVGQTRDIHWYRFDVMREPGAPADWLLEMGEAYIDHLDLFIPRVN
GAAGRPQDPAAYRLVRLGDFVPFSQRPMKTRLHSLPLTLPEGKPVSLYLRVDSVSAIRLS
ARVWSPAAYVSHQTKDLLFQGFFLGVLGILVLGYVALGLLLRDGALLSYTAYVATVFCYY
LFANGIGASLLPDLPGWLMNMLVGGSGFLGFATALIMWVYILDLQTRAPKLARCYQGLAL
LVLLASPTTVSPLYALTNPVVTLSALVVVVIALVLTARMAWLNPSDLSPRFYLASTLVSL
TGLIMAQLILRGALPADFFIADPYQVASMVAVLVLGTGLALRIGRLQAERLRAREESAFA
TKRAEEQRSFVAMLSHEFRTPLAAIDSAAQMIELSGAVESPSALTRLQRIRSTTHKMAEL
VDLFLSSDALDQGALALKPEPVALGQLMDEVLDGLTGTEAEERLELSIDAPDRPMLVDAP
FLGVAIGNLVQNALRYSPADTAVRVSAFDDGGGIVIRVADRGLGMTPEEMERIGSIYFRA
SSSRGTKGSGLGLYMTQKIVAAHGGTLSVESVRDQGSVFTILLPVTDGPPEAGHPLPHDR
F