Protein Info for MPMX19_01939 in Azospirillum sp. SherDot2

Annotation: 2,3-bisphosphoglycerate-independent phosphoglycerate mutase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 525 PF01676: Metalloenzyme" amino acids 9 to 504 (496 residues), 268.8 bits, see alignment E=7.6e-84 TIGR01307: phosphoglycerate mutase (2,3-diphosphoglycerate-independent)" amino acids 9 to 515 (507 residues), 676.5 bits, see alignment E=1.1e-207 PF06415: iPGM_N" amino acids 86 to 301 (216 residues), 246.9 bits, see alignment E=2.4e-77

Best Hits

Swiss-Prot: 58% identical to GPMI_RHOS4: 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (gpmI) from Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)

KEGG orthology group: K01834, phosphoglycerate mutase [EC: 5.4.2.1] (inferred from 95% identity to azl:AZL_023340)

Predicted SEED Role

"2,3-bisphosphoglycerate-independent phosphoglycerate mutase (EC 5.4.2.1)" in subsystem Entner-Doudoroff Pathway or Glycolysis and Gluconeogenesis or Glycolysis and Gluconeogenesis, including Archaeal enzymes (EC 5.4.2.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 5.4.2.1

Use Curated BLAST to search for 5.4.2.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (525 amino acids)

>MPMX19_01939 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (Azospirillum sp. SherDot2)
MTETNRPRPVVLCILDGWGYREERSDNAIALGETPNWDRLWSAEPTAFLDASEEEVGLPK
GQMGNSEVGHMNLGAGRVVMQDLVMIDHAIVEGDLERNAALNDLVKTMHRTGGRVHLMGL
MSPGGVHSHQDHIAALAGVLSREGVPVAVHAFTDGRDVPPQSAKDQVAEFMADVFELPGV
EVATVIGRYYAMDRDKRWDRVAKAYAAMTRAEGERAADPIQAIEQSYAADKHDEFILPTV
IGDYAGMKDGDAILMANFRADRAREILAAYVEKDFDGFPVASSPEGGAPKLAAVVGMVEY
SSALAKLMTTIFPPKTLTKVLGEVVSEAGLKQLRIAETEKYPHVTFFFNGGEERVYEGED
RILIPSPKVATYDLQPEMSASEVTGKLVGAIDSGKYDLIVVNFANPDMVGHSGMLDAAIK
AVQAVDSSVGQVEAAVRRAGGTMLITADHGNCELMKDPETGGPHTAHTLDKVPLVLVNGP
AGARIDSGRLADIAPTLLDLLGLPKPAEMTGRNLLVRTAARAAAE