Protein Info for MPMX19_01883 in Azospirillum sp. SherDot2

Annotation: Phosphoribosylformylglycinamidine synthase subunit PurL

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 741 PF18072: FGAR-AT_linker" amino acids 16 to 58 (43 residues), 53.8 bits, see alignment 3.3e-18 TIGR01736: phosphoribosylformylglycinamidine synthase II" amino acids 23 to 736 (714 residues), 933.6 bits, see alignment E=3.8e-285 PF00586: AIRS" amino acids 79 to 194 (116 residues), 100.2 bits, see alignment E=1.4e-32 amino acids 444 to 562 (119 residues), 85.1 bits, see alignment E=6.9e-28 PF02769: AIRS_C" amino acids 207 to 359 (153 residues), 131.8 bits, see alignment E=3.8e-42 amino acids 576 to 709 (134 residues), 70.4 bits, see alignment E=3e-23

Best Hits

Swiss-Prot: 72% identical to PURL_RHORT: Phosphoribosylformylglycinamidine synthase subunit PurL (purL) from Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIB 8255 / S1)

KEGG orthology group: K01952, phosphoribosylformylglycinamidine synthase [EC: 6.3.5.3] (inferred from 95% identity to azl:AZL_022860)

Predicted SEED Role

"Phosphoribosylformylglycinamidine synthase, synthetase subunit (EC 6.3.5.3)" in subsystem De Novo Purine Biosynthesis (EC 6.3.5.3)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 6.3.5.3

Use Curated BLAST to search for 6.3.5.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (741 amino acids)

>MPMX19_01883 Phosphoribosylformylglycinamidine synthase subunit PurL (Azospirillum sp. SherDot2)
MSAEATKAQERPVTAELAKEFGLSAEEYQNALDILGRTPTFTEMGIISVMWSEHCSYKSS
KVWLKTLPTTGPQVICGPGENAGVVDIGDGDAVIFKMESHNHPSYIEPYQGAATGVGGIL
RDVFTMGARPIANMNALRFGSPDHPKTRHLVSGVVAGIGGYGNCVGVPTVGGETNFHPAY
NGNILVNAMTVGVAKTDRIFYSAAAGIGNPVVYVGSKTGRDGIHGATMASAEFTEDSEEK
RPTVQVGDPFTEKLLIEACLELMETDAIVAIQDMGAAGLTSSSVEMAGKGGLGIELTLDT
LPMREEAMTPYEIMLSESQERMLIILKPGREEVAKAIFDKWELDFAVIGHLTDTGNLVIK
MYGETWCDMPIAPVSNAAPEYNRPWESTPKASDVADSVFDGYSEELGDTLTKLFGCPDLA
SKRWIWEQYDSLVGGDTRFMSGQADAAVVRVPGQTKAVAITTDCTPRYCLADPVEGGKQA
VAEAWRNLSAVGALPLAITDNMNFGNPEKPRIMGQFVGAVQGIGEACKALDFPVVSGNVS
LYNETNGEAILPTPAIGGVGIMPDAMIAVGIAFKNEGDVILAVGETKGHIGQSIFLREIL
GREEGAPPPVDLAVERRNGDFVRGLIHEGLVVSSHDAADGGLIVTIAEMALAGGIGAYLT
GFDGQHVRVLFGEDQGRYVLAVRPDVAATVQEKAKAAGVPVTVLGETRGTSLSGRGGEIV
SLKRLREANEGWLPTYMAAEL