Protein Info for MPMX19_01631 in Azospirillum sp. SherDot2

Annotation: Exodeoxyribonuclease 7 large subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 553 PF13742: tRNA_anti_2" amino acids 36 to 129 (94 residues), 95.8 bits, see alignment E=2.2e-31 TIGR00237: exodeoxyribonuclease VII, large subunit" amino acids 37 to 379 (343 residues), 397 bits, see alignment E=4.9e-123 PF01336: tRNA_anti-codon" amino acids 56 to 130 (75 residues), 50.4 bits, see alignment E=2.6e-17 PF02601: Exonuc_VII_L" amino acids 152 to 420 (269 residues), 296.4 bits, see alignment E=4.6e-92 amino acids 352 to 508 (157 residues), 73.9 bits, see alignment E=2.5e-24

Best Hits

Swiss-Prot: 71% identical to EX7L_RHOCS: Exodeoxyribonuclease 7 large subunit (xseA) from Rhodospirillum centenum (strain ATCC 51521 / SW)

KEGG orthology group: K03601, exodeoxyribonuclease VII large subunit [EC: 3.1.11.6] (inferred from 92% identity to azl:AZL_019860)

Predicted SEED Role

"Exodeoxyribonuclease VII large subunit (EC 3.1.11.6)" in subsystem DNA repair, bacterial (EC 3.1.11.6)

Isozymes

Compare fitness of predicted isozymes for: 3.1.11.6

Use Curated BLAST to search for 3.1.11.6

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (553 amino acids)

>MPMX19_01631 Exodeoxyribonuclease 7 large subunit (Azospirillum sp. SherDot2)
MAAPQLKSAMTSENAPQTSTPLIAPEPRPGSNLPEFTVGDLARRLKRSIEEEFGFVRVRG
EISQPKKHSSGHCYMRLKDDTAVIEAVCWRGTMAKLAVRPEEGLEVIVTGRMTTYPGRSQ
YQLIVESMELAGEGALLKMLEERKRRLAAEGLFDPARKKRIPFLPDVIGVVTSPTGAVIR
DILHRLNDRFPRHVLLWPVAVQGERAAAEVTAAIEGFNRIQPGGRVPRPDLIIVARGGGS
LEDLMAFNEENVVRAAAASAIPLISAVGHETDTTLIDFASDLRAPTPTAAAEMAVPVRGE
LLAQILDDERRLLACASRAVEDRRNRVEGLARGLGDPRALLEGHAQRLDDRAERLNLAAS
ALLERRRTRVGELAAKLRHPREKLAQAEQKLASESRALDSGLRHAVTTAGGRFDRVAGRL
SLTPARVKLADGERRIADLTPRLDRSHAKGVADKAASLASLGQLLESYSYKGVLARGFAL
VEDRDGRPVTRADQATPGLAVNIVFADDAKVAATVDGGAPKVEMKPEAEVEPKPEKKPAP
RKPRPVPVQGSLF