Protein Info for MPMX19_01439 in Azospirillum sp. SherDot2

Annotation: Multidrug resistance protein MdtC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1039 signal peptide" amino acids 1 to 29 (29 residues), see Phobius details transmembrane" amino acids 334 to 353 (20 residues), see Phobius details amino acids 360 to 381 (22 residues), see Phobius details amino acids 387 to 411 (25 residues), see Phobius details amino acids 431 to 453 (23 residues), see Phobius details amino acids 463 to 482 (20 residues), see Phobius details amino acids 528 to 548 (21 residues), see Phobius details amino acids 855 to 874 (20 residues), see Phobius details amino acids 881 to 901 (21 residues), see Phobius details amino acids 907 to 932 (26 residues), see Phobius details amino acids 953 to 976 (24 residues), see Phobius details amino acids 984 to 1009 (26 residues), see Phobius details PF00873: ACR_tran" amino acids 4 to 1010 (1007 residues), 1037.6 bits, see alignment E=0 PF02355: SecD_SecF_C" amino acids 329 to 479 (151 residues), 22.2 bits, see alignment E=8.3e-09 amino acids 854 to 1010 (157 residues), 22.3 bits, see alignment E=8e-09

Best Hits

Swiss-Prot: 49% identical to MDTC_ENT38: Multidrug resistance protein MdtC (mdtC) from Enterobacter sp. (strain 638)

KEGG orthology group: K03296, hydrophobic/amphiphilic exporter-1 (mainly G- bacteria), HAE1 family (inferred from 93% identity to azl:AZL_017620)

MetaCyc: 48% identical to multidrug efflux pump RND permease subunit MdtC (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-352; TRANS-RXN-353; TRANS-RXN-92

Predicted SEED Role

"Acriflavin resistance protein" in subsystem Multidrug Resistance Efflux Pumps

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1039 amino acids)

>MPMX19_01439 Multidrug resistance protein MdtC (Azospirillum sp. SherDot2)
MNLSELCIRRPVMTILLTAALVLSGLAAYRQLPTAALPRVDFPVVSVTATLPGASPETMA
ASVASPLEREFSTIAGIDTITSNSTLGNTSITIQFVLERDIDAAAADVQAAIARTQRRLP
AEMTTPPSYRKVNPADQPILFLSLNSPTLPLAQLNDIAETLIQPKVATLPGVAQVQIYGS
QKYAVRVQVNPNALALRGIGIDELQKALAAANANTPVGTLTGQQQQLVIAANPQLPDAAA
FRQLIVAYRNSAPVRLGDVAQVLDSVENDRTASWLNGTRSIMLAVQRQPDANTVDVVDRV
RELVPVFQTQLPAAAAIQVVNDRSESIRQAVEDVQFTLGLTIVLVVMVIFLFLRRLSATL
IPALAVPISLIATAGGMHLLGFSVDNISLMALTLAVGLVVDDAIVMMENIVRYVEEGMKP
FEAAIKGSREIGFTILSITLSLVAVFIPILLMGGVVGRLFHEFALVVTMSIGASAFVSLT
LTPMMCSRFLTHAHDQKEGWFGRMLEGGFSAVLNGYARTLRWTLRHRPLMGLVMIGTVIG
TALLYQAIPKGFFPTEDIGQIQVTTEARADIAFPSMAERQQQVAAIIKANPAVVDVISSV
GVGGSTGNQGRMFLTLKPRDERPSATEVIQQIRRQVNGIPGMAVYMQPVQNLRIGGRASK
SLYQYTIQGLDLDELYQWSGRLEQTLRGIPILQDVTSDLQLNNPQAYVHIDREKAATLGL
GVDQVRSTLYSAFGQRQVSTIYTPSNDYQVLIELEPKYQGDDSSLSRIYVRSTTTGKLVP
LDAFARVERTAGPLAVNHQGQLPAVTLSFNLAPGASLGQAVDLIRASEREMGLPPTVTTG
FAGTAQVFQDAQAGQALLLSAAVLVIYIVLGVLYESFIHPLTILSGLPSAAIGALATLML
FDVELSVIAIIGILMLIGIVKKNAIMMIDFAVDARRNGMSARDAIEQACLLRFRPIIMTT
MAAIMGTLPIAIAHGAAAELRQPLGLAVVGGLCVSQVLTLYITPSLYLYMEDFGHFMSNL
FRSRKADIPHGPMPAGGDD