Protein Info for MPMX19_01122 in Azospirillum sp. SherDot2

Annotation: Putative thiamine biosynthesis protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 313 signal peptide" amino acids 1 to 23 (23 residues), see Phobius details PF13379: NMT1_2" amino acids 25 to 179 (155 residues), 35.2 bits, see alignment E=1.2e-12 PF09084: NMT1" amino acids 35 to 246 (212 residues), 249 bits, see alignment E=4.8e-78

Best Hits

Swiss-Prot: 59% identical to Y357_HAEIN: Putative thiamine biosynthesis protein HI_0357 (HI_0357) from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

KEGG orthology group: K02051, sulfonate/nitrate/taurine transport system substrate-binding protein (inferred from 96% identity to azl:AZL_014950)

Predicted SEED Role

"Hydroxymethylpyrimidine ABC transporter, substrate-binding component" in subsystem Thiamin biosynthesis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (313 amino acids)

>MPMX19_01122 Putative thiamine biosynthesis protein (Azospirillum sp. SherDot2)
MKHLFTAGLIAAGLMTSLPALAQDKLSVMLDWFVNPDHAPLVVAQEKGFFKDAGLEVTLT
APADPNDPPKLVAAGGADIAVSYQPQLILQVAEELPLVRIGTLVSTPLNSVVVLRDGPVK
TLKDLKGRKVGYSIAGFEDALLGAMLEKQGLSLKDVELVNVNFSLSPSLLSGQVDAVVGA
FRNFELNQMEIEKHPGRAFYPEEEGVPPYDELILVARKDKVNDPRFKRFLAAVERATLYI
LNHPEESQAAFVKGRPELNDELNRRAWADTLPRFSHSPAALDAERYTRFAEFLKARGLIK
AVAPVDQYAVVVK