Protein Info for MPMX19_00995 in Azospirillum sp. SherDot2

Annotation: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00243: 1-deoxy-D-xylulose 5-phosphate reductoisomerase
  • amino acids 10 to 387 (378 residues), 463.4 bits, E=2.9e-143
• PF02670: DXP_reductoisom
  • amino acids 11 to 136 (126 residues), 140.5 bits, E=7.6e-45
• PF08436: DXP_redisom_C
  • amino acids 150 to 233 (84 residues), 127 bits, E=3.9e-41
• PF13288: DXPR_C
  • amino acids 265 to 381 (117 residues), 137.1 bits, E=5e-44

Best Hits

Swiss-Prot: 74% identical to DXR_RHOCS: 1-deoxy-D-xylulose 5-phosphate reductoisomerase (dxr) from Rhodospirillum centenum (strain ATCC 51521 / SW)

KEGG orthology group: K00099, 1-deoxy-D-xylulose-5-phosphate reductoisomerase [EC: 1.1.1.267] (inferred from 93% identity to azl:AZL_016200)

Predicted SEED Role

"1-deoxy-D-xylulose 5-phosphate reductoisomerase (EC 1.1.1.267)" in subsystem Isoprenoid Biosynthesis or polyprenyl synthesis (EC 1.1.1.267)

MetaCyc Pathways

• superpathway of geranylgeranyl diphosphate biosynthesis II (via MEP) (11/12 steps found)
• taxadiene biosynthesis (engineered) (11/13 steps found)
• methylerythritol phosphate pathway I (8/9 steps found)
• methylerythritol phosphate pathway II (8/9 steps found)
• isoprene biosynthesis I (8/10 steps found)
• superpathway of ergosterol biosynthesis II (12/26 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from terpenoid and polyketide
• Biosynthesis of plant hormones
• Biosynthesis of terpenoids and steroids
• Terpenoid biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.267

Protein Sequence (398 amino acids)

>MPMX19_00995 1-deoxy-D-xylulose 5-phosphate reductoisomerase (Azospirillum sp. SherDot2)
MVVKADAPRSVTILGSTGSVGTQTVDLVSRDPERFPVEALTANRNVTLLAQQARQLNARM
AVVADPAAYAELKQLLSGTGIEVAAGSEAVAAAAERPADWVMAAIVGAAGLEPTLAAIRR
GAIVAFANKEVLVCAGALMMEEVKAHGATLLPVDSEHSAIYQVFDFERTDSVSRLILTAS
GGPFRDKDRAFMAAATREQAVAHPTWDMGAKISVDSATMMNKGLELIEAHFLFGVPEERI
DVLVHPQSVIHSLVEYVDGSVLAQLGTPDMRTPIAYALGWPARIATPAERLDLVKAATLT
FEAPDPVRFPALRLARAALQSGGGAPTILSAANEVAVQAFLDRRIGFLDIERIVEETLTA
LPHRPLRDLAAVREADADARRDAAGRVAAIGATAVGSR