Protein Info for MPMX19_00884 in Azospirillum sp. SherDot2

Annotation: Cytochrome c oxidase subunit 2

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 282 signal peptide" amino acids 1 to 28 (28 residues), see Phobius details transmembrane" amino acids 51 to 75 (25 residues), see Phobius details amino acids 96 to 118 (23 residues), see Phobius details PF02790: COX2_TM" amino acids 30 to 116 (87 residues), 89.1 bits, see alignment E=1.8e-29 TIGR02866: cytochrome c oxidase, subunit II" amino acids 51 to 256 (206 residues), 209.7 bits, see alignment E=1.7e-66 PF00116: COX2" amino acids 128 to 247 (120 residues), 197.4 bits, see alignment E=5.5e-63

Best Hits

Swiss-Prot: 59% identical to COX2_RICBR: Probable cytochrome c oxidase subunit 2 (ctaC) from Rickettsia bellii (strain RML369-C)

KEGG orthology group: K02275, cytochrome c oxidase subunit II [EC: 1.9.3.1] (inferred from 93% identity to azl:AZL_012280)

Predicted SEED Role

"Cytochrome c oxidase polypeptide II (EC 1.9.3.1)" in subsystem Terminal cytochrome C oxidases (EC 1.9.3.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.9.3.1

Use Curated BLAST to search for 1.9.3.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (282 amino acids)

>MPMX19_00884 Cytochrome c oxidase subunit 2 (Azospirillum sp. SherDot2)
MRRQSLYAAGLAAVLSMVGGLSTAALANEPRPWEMGMQPSASPVKHLMTSFNDLLTVVIT
LIVIFVAGLMAYCVVRFNAKRNPVPSRTSHHTLLEVAWTVVPVIILIVIAVPSFKLLYAA
ERIPQADMTIKVIGHQWYWDYEYPDHGNITFSSYMIAEADLKPGQKRLLEVDNRVVVPVN
TTVRVLVTAGDVIHSWAVPAFGLKKDGVPGRINETWFKAEREGVYYGQCSEICGTNHGFM
PIAVEAVSKEAFDAWVAKAKTAYAPKDGDRDVAQRPTGTLVE