Protein Info for MPMX19_00618 in Azospirillum sp. SherDot2

Annotation: Sorbitol dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF08240: ADH_N
  • amino acids 36 to 156 (121 residues), 98.5 bits, E=3.9e-32
• PF16912: Glu_dehyd_C
  • amino acids 161 to 360 (200 residues), 40.1 bits, E=4.5e-14
• PF00107: ADH_zinc_N
  • amino acids 195 to 321 (127 residues), 117.1 bits, E=8.1e-38

Best Hits

KEGG orthology group: None (inferred from 97% identity to azl:AZL_009040)

Predicted SEED Role

"2,3-butanediol dehydrogenase, R-alcohol forming, (R)- and (S)-acetoin-specific (EC 1.1.1.4)" in subsystem Acetoin, butanediol metabolism (EC 1.1.1.4)

MetaCyc Pathways

• superpathway of (R,R)-butanediol biosynthesis (4/5 steps found)
• (R,R)-butanediol biosynthesis (1/1 steps found)
• (R,R)-butanediol degradation (1/1 steps found)

KEGG Metabolic Maps

• Butanoate metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.1.1.4

Use Curated BLAST to search for 1.1.1.4

Protein Sequence (376 amino acids)

>MPMX19_00618 Sorbitol dehydrogenase (Azospirillum sp. SherDot2)
MNAINKDLATTMKAAVWHGRKDIRVEDVPLPGAPPAGWVQIKVHWCGICGSDLHEYVAGP
VFIPVDTPHPLTGLKGQCILGHEFSGEIATLGEGVTGFAVGDRVAADACQHCGECYYCKH
GMYNICEKLAFTGLMNNGAFASLVNVPAELLYKLPDGFPTEAGALIEPLAVGMHAVKKAG
SIVGETVVVVGAGTIGLCTIMCAKAAGAGRIIVLEMSAARKAKALEVGATLVLDPKECDA
VAEVKALTGGYGADVSFECIGHRDTAKLAIDVIRKAGKTVLVGIFEEPSAFNFFEIVATE
KQIIGSLAYNGEFADVIRFIADGRIDVQPLITGRITLSDIVSGGFEELVAHKDRNVKIIV
QPQAVTAAADQPELVH