Protein Info for MPMX19_00503 in Azospirillum sp. SherDot2

Annotation: ATP-dependent Clp protease ATP-binding subunit ClpA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 771 TIGR02639: ATP-dependent Clp protease ATP-binding subunit ClpA" amino acids 3 to 738 (736 residues), 1149 bits, see alignment E=0 PF02861: Clp_N" amino acids 13 to 62 (50 residues), 48.3 bits, see alignment 5.9e-16 PF00004: AAA" amino acids 215 to 347 (133 residues), 47.7 bits, see alignment E=1.4e-15 amino acids 496 to 622 (127 residues), 44.3 bits, see alignment E=1.6e-14 PF07728: AAA_5" amino acids 217 to 293 (77 residues), 24.4 bits, see alignment E=1.7e-08 amino acids 496 to 612 (117 residues), 50.2 bits, see alignment E=1.8e-16 PF17871: AAA_lid_9" amino acids 354 to 453 (100 residues), 93.3 bits, see alignment E=5.2e-30 PF07724: AAA_2" amino acids 490 to 651 (162 residues), 194 bits, see alignment E=1.3e-60 PF13401: AAA_22" amino acids 494 to 587 (94 residues), 29.3 bits, see alignment E=6.4e-10 PF10431: ClpB_D2-small" amino acids 657 to 737 (81 residues), 92.3 bits, see alignment E=1e-29

Best Hits

Swiss-Prot: 72% identical to CLPA_RHOBL: ClpA homolog protein from Rhodobacter blasticus

KEGG orthology group: K03694, ATP-dependent Clp protease ATP-binding subunit ClpA (inferred from 100% identity to azl:AZL_006860)

Predicted SEED Role

"ATP-dependent Clp protease ATP-binding subunit ClpA" in subsystem Proteolysis in bacteria, ATP-dependent

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (771 amino acids)

>MPMX19_00503 ATP-dependent Clp protease ATP-binding subunit ClpA (Azospirillum sp. SherDot2)
MLSRNLEQTLHRALAHANERRHEYATLEHLLLALTEDSDATAVLRACGIDLDRLRAELSD
YLDNELANLITNRPDDAKPTAGFQRVLQRAAIHVQSSGREEVTGANVLVALFSERESHAV
YFLQEQEMTRFDAVNYISHGIAKAPGRSETKRVSGADDEAAAEKVVKKGSEALEAYCVNL
NKKASGGKIDPLIGREQEVERTIQILCRRSKNNPLYVGDPGVGKTAIAEGLARRIVQQEV
PEVLRNATIFALDMGSLLAGTRYRGDFEERLKAVVSELEATEGAILFIDEIHTVIGAGAT
SGGAMDASNLLKPALASGSLRCIGSTTYKEYRSYFEKDRALVRRFQKIDVNEPSVEDAIK
ILQGLKPYYEKHHKVTYTNDAIRVAVELSAKYIGDRKLPDKAIDIIDEVGAAQMLLPENK
RRKKIGVKDVEAVVAKIARIPPKSVSRDDKETLLNLERDLKTMVFGQNKAIDALVSAIKL
ARAGLREPEKPIGNYLFTGPTGVGKTEVARQLAMTLGIELTRFDMSEYMERHTVSRLIGA
PPGYVGFDQGGMLTDAIDQHPHCVLLLDEIEKAHPDLFNILLQIMDHGKLTDHNGKIVDF
RNVILIMTSNAGAADMAKPAIGFERDRRVGEDIEAVEKMFTPEFRNRLDAIIPFAPLTQE
VINRVVDKFIMQMEAQLEDRGVSIELNEEAREWLGKKGYDPLYGARPLGRVIQEYIKKPL
AEELLFGKLSKGGLVKVTVKDDKPAFDYTEGNRPKRTSGDDDEEMVSEMVE