Protein Info for MPMX19_00310 in Azospirillum sp. SherDot2

Annotation: 3-methylmercaptopropionyl-CoA dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 598 PF12418: AcylCoA_DH_N" amino acids 2 to 29 (28 residues), 38.3 bits, see alignment (E = 3.8e-13) PF02771: Acyl-CoA_dh_N" amino acids 40 to 156 (117 residues), 43.1 bits, see alignment E=1.7e-14 PF02770: Acyl-CoA_dh_M" amino acids 161 to 264 (104 residues), 45.7 bits, see alignment E=2.2e-15 PF00441: Acyl-CoA_dh_1" amino acids 283 to 448 (166 residues), 93.6 bits, see alignment E=5e-30 PF22924: ACOX_C_alpha1" amino acids 293 to 443 (151 residues), 33.1 bits, see alignment E=1.7e-11 PF08028: Acyl-CoA_dh_2" amino acids 299 to 442 (144 residues), 30.2 bits, see alignment E=1.8e-10 PF12806: Acyl-CoA_dh_C" amino acids 465 to 593 (129 residues), 90.7 bits, see alignment E=3e-29

Best Hits

KEGG orthology group: None (inferred from 94% identity to azl:AZL_005040)

Predicted SEED Role

"Acyl-CoA dehydrogenase (EC 1.3.8.7)" (EC 1.3.8.7)

MetaCyc Pathways

Isozymes

Compare fitness of predicted isozymes for: 1.3.8.7

Use Curated BLAST to search for 1.3.8.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (598 amino acids)

>MPMX19_00310 3-methylmercaptopropionyl-CoA dehydrogenase (Azospirillum sp. SherDot2)
MTYTAPVDDLRFVLNEVVGLDAIAALPHCDSAAPDLVDAILEEAGKFASGVLAPLNRVGD
KEGAKLENGVVRTATGWKEAYGQFTEAGWNSLPFEPEYGGQGLPWTVAFAVNEMWQAANL
SFGLCPLLTQGAVDLLTEHASDEQKAVYLSKMISGEWTGTMNLTEPQAGSDLAAVRTKAV
RAGDGSYRITGQKIFITYGEHDLTENIVHLVLARLPDAPAGIKGISLFIVPKFLPNADGT
PGQRNDLRCASLEHKLGIMASPTAVMAYGDDEGAIGYLVGEENRGIEYMFTMMNNARLGV
GIQGVAIAERAYQQGRAYARSRVQSKDLADPRGSGVAIIKHPDVRRMLLDMRAKTEAARA
LALYAGTQLDISRHHEDPAVRAAATARVDVLTPIVKAWSTDIGCEVASTGVQIHGGMGFI
EETGAAQHYRDARITPIYEGTNGIHGNDLTFRKTGRDKGAAARAFVADMRATVEELGAAP
GDDLAVIRTELSAGLDALDRAIDWMVATQAEGDLQGAAAGAVAYLKLWGTVAGGWMLARS
AMKAMAGLRQPGANASFLESKLIVARFYAEQVLATAPALLPTIASARNTVMALSEEQF