Protein Info for MPMX19_00232 in Azospirillum sp. SherDot2

Annotation: Thioredoxin reductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 334 PF07992: Pyr_redox_2" amino acids 8 to 304 (297 residues), 191.8 bits, see alignment E=7.3e-60 TIGR01292: thioredoxin-disulfide reductase" amino acids 8 to 315 (308 residues), 412.4 bits, see alignment E=4e-128 PF00890: FAD_binding_2" amino acids 9 to 43 (35 residues), 20.4 bits, see alignment 1e-07 PF13738: Pyr_redox_3" amino acids 83 to 287 (205 residues), 66.4 bits, see alignment E=1.1e-21 PF00070: Pyr_redox" amino acids 150 to 216 (67 residues), 62.8 bits, see alignment E=1.4e-20

Best Hits

Swiss-Prot: 65% identical to TRXB_RICBR: Thioredoxin reductase (trxB) from Rickettsia bellii (strain RML369-C)

KEGG orthology group: K00384, thioredoxin reductase (NADPH) [EC: 1.8.1.9] (inferred from 97% identity to azl:AZL_003630)

Predicted SEED Role

"Thioredoxin reductase (EC 1.8.1.9)" in subsystem Glycine reductase, sarcosine reductase and betaine reductase or Thioredoxin-disulfide reductase or Wyeosine-MimG Biosynthesis (EC 1.8.1.9)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.8.1.9

Use Curated BLAST to search for 1.8.1.9

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (334 amino acids)

>MPMX19_00232 Thioredoxin reductase (Azospirillum sp. SherDot2)
MATTHHTKVLIIGAGPAGYTAAIYAARANLEPLMVQGMQPGGQLMITTDVENFPGFADPI
QGPWLMEQMQKQAEHVGTRMVFDLITDVDFTKRPFVCKGDSGDTYTADSVIIATGAQARW
LGISTEEIYRGFGVSACATCDGFFFRGKEIAVIGGGNSAVEEALYLTNHASKVTVIHRRD
SFRAERIMQDRLFRHPKIEVVWDSTVEEIVGEGDGTMGNPRAVTGVRIKNVKSGDERVIP
VAGVFVAIGHVPATGIFQGKVEMDDSGYIVTVPDSTATNIPGVFAAGDVKDKVYRQAVTA
AGMGCMAALEAERWLAHHEPAAGAHGDPSPAGTW