Protein Info for MPMX19_00211 in Azospirillum sp. SherDot2

Annotation: putative copper-importing P-type ATPase A

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 844 transmembrane" amino acids 171 to 192 (22 residues), see Phobius details amino acids 204 to 221 (18 residues), see Phobius details amino acids 241 to 259 (19 residues), see Phobius details amino acids 265 to 283 (19 residues), see Phobius details amino acids 421 to 444 (24 residues), see Phobius details amino acids 452 to 475 (24 residues), see Phobius details amino acids 745 to 762 (18 residues), see Phobius details amino acids 768 to 787 (20 residues), see Phobius details PF12156: ATPase-cat_bd" amino acids 4 to 58 (55 residues), 39.8 bits, see alignment 1.3e-13 PF00403: HMA" amino acids 88 to 147 (60 residues), 51 bits, see alignment 3e-17 TIGR01511: copper-translocating P-type ATPase" amino acids 222 to 788 (567 residues), 495.7 bits, see alignment E=4.2e-152 TIGR01525: heavy metal translocating P-type ATPase" amino acids 239 to 788 (550 residues), 513.7 bits, see alignment E=1.5e-157 TIGR01512: cadmium-translocating P-type ATPase" amino acids 269 to 790 (522 residues), 343.9 bits, see alignment E=3.2e-106 TIGR01494: HAD ATPase, P-type, family IC" amino acids 272 to 514 (243 residues), 107.8 bits, see alignment E=9.7e-35 amino acids 613 to 772 (160 residues), 98.4 bits, see alignment E=6.8e-32 PF00122: E1-E2_ATPase" amino acids 302 to 482 (181 residues), 152.3 bits, see alignment E=2.1e-48 PF00702: Hydrolase" amino acids 498 to 699 (202 residues), 106.4 bits, see alignment E=5.1e-34

Best Hits

KEGG orthology group: K01533, Cu2+-exporting ATPase [EC: 3.6.3.4] (inferred from 92% identity to azl:AZL_003400)

Predicted SEED Role

"Type cbb3 cytochrome oxidase biogenesis protein CcoI; Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.4)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.4

Use Curated BLAST to search for 3.6.3.4

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (844 amino acids)

>MPMX19_00211 putative copper-importing P-type ATPase A (Azospirillum sp. SherDot2)
MTVCLHCGQELGDNAQAGSPTAGDGAGPFCCTGCAAAYDLVRGLGLERYYERRSVDPTAR
PLRPDDAPAVDYEPHARDEQDGSRSLHLMVDGMQCAACVWLIESALNRQPGVAQARMNMT
TRRLTVRWDPKATDANAVVGTVAQLGYRAVPFDPDRLGGAQAKSEKELLRAMAVAGFAMG
NVMLLSVSVWAGHSQGMGTATRDLMHWISALICMPAIAYALRPFARSALSALSHGRTNMD
VPITIGVLLATGMSLFETIHSGEHAYFDGGVMLLFFLLVGRYLDQRARGRARSAAEQLLG
LRANAVTILNADGTSAVVAPEQVVPGTVILVAAGERIPVDGRVSDGVSDLDTGLITGETV
PGTARPGDQVFAGTLNLTAPLRLTVTAVGEGTLLAEIVRLMEVAEQGRAKYVAIADRVSR
LYAPVVHLTALTTFAGWMLLGGVVWQDALMNAIAVLIITCPCALALAVPVVQVIASGRLM
RQGTLLKSPTALERLAAIDTVVFDKTGTLTEGRPVPQLDGLAAERLSAEDLALAASLAAA
SRHPLARALAAAAPEVPVAAGVREIAGAGLSLQTADGEVRLGSRRFTCAPLEAEDAAGPE
LWLARPGEEPRRIVFLDAPRPDAAAVVAALKARGLEVKLLSGDRRGAVAAVAERLGIADW
RAEQTPADKTAVLAELAGQGRTVLMVGDGLNDAPALAAAAVSMSPSTAVDVSQTAADVVF
QGRLLRPIVETVEVSRRSGRLVRQNFGIALVYNLCAVPLAMGGMLTPLLAALAMSSSSLI
VILNALRLARGAVVKDLPVRDIAVRELPGKDSGDGRASLSDRDRAEPGRAGAGGLSVGAE
IRPV